{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:13:19Z","timestamp":1785795199347,"version":"3.56.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T00:00:00Z","timestamp":1658188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Rosacea is a chronic inflammatory skin condition of varying severity that can significantly impact patient quality of life. Intense pulsed light (IPL) is an established treatment for rosacea\u2010associated telangiectasia, inflammation, and erythema.<\/jats:p><jats:p>This study assessed whether application of a phyto\u2010corrective mask, gel, and resveratrol antioxidant serum after IPL treatment can improve outcomes and reduce procedure\u2010related adverse effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a prospective, open\u2010label, split\u2010face, 3\u2010month study, 10 subjects with moderate\u2010to\u2010severe facial rosacea underwent IPL treatment on both sides of the face. The following were applied to the right side of the face only: phyto\u2010corrective mask once weekly starting immediately after IPL; phyto\u2010corrective gel twice daily; and resveratrol antioxidant treatment at night. Both sides of the face were treated with sunscreen. Subjects were assessed on Day 1, 1 and 3\u00a0months after IPL by three, independent evaluators using the 5\u2010point Global Aesthetic Improvement Scale (GAIS). All subjects rated skin redness, hydration, and overall improvement on Day 1 and completed a patient satisfaction questionnaire at the 1\u2010 and 3\u2010month visits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten women were enrolled, aged 44\u201372\u2009years old, with moderate (<jats:italic>n<\/jats:italic>\u00a0=\u00a06) to severe (<jats:italic>n<\/jats:italic>\u00a0=\u00a04) rosacea. IPL was effective at reducing symptoms with rosacea classified as absent in five women and mild in five at the final 3\u2010month visit. GAIS scores also revealed improvements on both sides of the face, but the skincare treated side showed continuous improvement over 3\u00a0months with all patients remaining at least \u201cImproved\u201d, whereas there appeared to be a waning effect after 1\u00a0month with IPL alone. On Day 1 after IPL, all women reported less redness, improved hydration, and improved skin appearance on the right side of the face. Patient satisfaction was consistently rated higher on the right side of the face.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Application of a phyto\u2010corrective mask, gel, and resveratrol antioxidant serum may complement IPL treatment for rosacea by enhancing treatment outcomes and reducing procedure\u2010related symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15189","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T06:53:59Z","timestamp":1656485639000},"page":"3759-3767","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Integrative skincare trial of intense pulsed light followed by the phyto\u2010corrective mask, phyto\u2010corrective gel, and resveratrol <scp>BE<\/scp> for decreasing post\u2010procedure downtime and improving procedure outcomes in patients with rosacea"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8367-8663","authenticated-orcid":false,"given":"Sheila C.","family":"Barbarino","sequence":"first","affiliation":[{"name":"Barbarino Surgical Arts  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian W.","family":"Bucay","sequence":"additional","affiliation":[{"name":"Bucay Center for Dermatology and Aesthetics  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel L.","family":"Cohen","sequence":"additional","affiliation":[{"name":"University of California  Irvine California USA"},{"name":"AboutSkin Dermatology and DermSurgery  Greenwood Village Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5183-5433","authenticated-orcid":false,"given":"Michael\u00a0H.","family":"Gold","sequence":"additional","affiliation":[{"name":"Gold Skin Care Center Tennessee Clinical Research Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,19]]},"reference":[{"issue":"6","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/ddg.13139","article-title":"Pathogenesis and clinical presentation of rosacea as a key for a symptom\u2010oriented therapy","volume":"14","author":"Reinholz M","year":"2016","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16481"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.08.049"},{"key":"e_1_2_11_5_1","unstructured":"DrakeL.Rosacea now estimated to affect at least 16 million American. 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