{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T03:40:30Z","timestamp":1787370030462,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>During the ongoing COVID\u201019 outbreak, face mask use has increased and became a part of our daily lives. While wearing, prolonged contact time and microenvironmental change profoundly lead to an acne flare\u2010up, defined as \u201cmaskne.\u201d<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We aimed to assess the efficacy and safety of snail secretion filtrate, <jats:italic>Calendula officinalis<\/jats:italic>, and <jats:italic>Glycyrrhiza glaba<\/jats:italic> root extract combination serum (SCGS) in treating the maskne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a randomized, double\u2010blind, placebo\u2010controlled trial study. This study enrolled 66 participants with mild\u2010to\u2010moderate maskne. The SCGS and placebo were randomly assigned for participants to use twice daily for 12\u2009weeks. Percentage change of acne lesion count, acne severity by Investigator Global Evaluation Acne (IGEA), sebum levels, corneometry levels, transepidermal water loss (TEWL), erythema score by Visia\u00ae, and adverse events were evaluated 4\u2010weekly at baseline to Week 12. At Week 12, all participants evaluated their satisfaction scores using a 10\u2010point visual analog scale (VAS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the mask\u2010covered area, the percent reduction in inflammatory acne lesions from the treatment group was significantly greater than the placebo group at all time points (coefficient of percentage change of inflammatory lesions\u00a0=\u00a0\u221233.89 [95% CI \u221265.24, \u22122.53]; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.03). Also, a subgroup analysis with participants using concurrent acne treatments revealed similar results (12 participants, coefficient\u00a0=\u00a0\u221250.30 [95% \u221288.65, \u221211.95]; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.01). However, there were no significant differences in non\u2010inflammatory lesions, all skin biophysics, and VAS between groups. Adverse events were mild and occurred in a few cases in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The SCGS could significantly improve inflammatory acne lesions and had a favorable tolerability profile, suggesting its role as an adjunctive treatment in maskne.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15190","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T18:44:54Z","timestamp":1656441894000},"page":"4470-4478","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Efficacy and safety of a facial serum containing snail secretion filtrate, <i>Calendula officinalis<\/i>, and <i>Glycyrrhiza glaba<\/i> root extract in the treatment of maskne: A randomized placebo\u2010controlled 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