{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:49:13Z","timestamp":1791488953879,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:00:00Z","timestamp":1659916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:00:00Z","timestamp":1659916800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acne vulgaris is a chronic inflammatory skin disease. If skin lesions are not treated well in time, they can leave a permanent impact on the appearance and a negative influence on personal confidence. The common therapy for acne symptom includes antibiotics, benzoyl peroxide, and azeleic acid. However, those medications have side effects, and the long\u2010term use should be cautious. Therefore, it is necessary to develop a safe and effective material, which is more suitable for daily use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Collagen was selected to co\u2010ferment with three probiotic strains TYCA06\/AP\u201032\/CP\u20109 (TAC) due to its excellent feature on wound healing. The fermented material was added into cosmetic gel and applied on subjects' acne lesions. The antimicrobial activity against\n                      <jats:italic>Propionibacterium acnes<\/jats:italic>\n                      and anti\u2010inflammation effect around lesion area were investigated in a 4\u2010week clinical study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      An anti\u2010\n                      <jats:italic>P. acnes<\/jats:italic>\n                      assay, a keratinocytes HaCaT cell\u2010based wound healing assay, and a cytokine assay on thymic stromal lymphopoietin (TSLP) and interleukin (IL)\u201033 were used to evaluate the function of the fermented material in vitro. The TAC\/Collagen formula was further incorporated into a cosmetic gel, and the human clinical trial was carried out by applying this gel on 20 volunteers' face with acne vulgaris. The moisture score, sebum content, inflammation, porphyrins numbers, and brown spot number of whole face were observed and recorded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The postbiotics of the TAC\/Collagen displayed a good growth inhibition against\n                      <jats:italic>P. acnes<\/jats:italic>\n                      and reduced TSLP and IL\u201033 inflammation in vitro. This TAC\/Collagen formula enhanced the wound healing in HaCaT cell culture. The result of the clinical trial showed the TAC\/Collagen gel improved the moisture score and inflammation index of the skin in vivo. In addition, this TAC\/Collagen gel also improved the wound healing of acne symptom in volunteers with acne vulgaris. Moreover, this TAC\/Collagen gel reduced the number of the porphyrins and brown spots on facial skin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These postbiotics of TAC\/Collagen have beneficial effects on skin health and are able to ameliorate the redness, inflammation, and acne symptom in acne vulgaris patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.15228","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T00:19:42Z","timestamp":1657585182000},"page":"6249-6260","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Novel application of a\n                    <scp>Co\u2010Fermented<\/scp>\n                    postbiotics of\n                    <scp>TYCA06<\/scp>\n                    \/\n                    <scp>AP<\/scp>\n                    \u201032\/\n                    <scp>CP<\/scp>\n                    \u20109\/collagen in the improvement of acne vulgaris\u2014A randomized clinical study of efficacy evaluation"],"prefix":"10.1111","volume":"21","author":[{"given":"Hsieh\u2010Hsun","family":"Ho","sequence":"first","affiliation":[{"name":"Glac Biotech Co., Ltd.  Tainan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching\u2010Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Glac Biotech Co., Ltd.  Tainan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsai\u2010Hsuan","family":"Yi","sequence":"additional","affiliation":[{"name":"Glac Biotech Co., Ltd.  Tainan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Fen","family":"Huang","sequence":"additional","affiliation":[{"name":"Glac Biotech Co., Ltd.  Tainan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Wei","family":"Kuo","sequence":"additional","affiliation":[{"name":"Glac Biotech Co., Ltd.  Tainan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Hung","family":"Lin","sequence":"additional","affiliation":[{"name":"Glac Biotech Co., Ltd.  Tainan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jui\u2010Fen","family":"Chen","sequence":"additional","affiliation":[{"name":"Glac Biotech Co., Ltd.  Tainan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin\u2010Yu","family":"Tsai","sequence":"additional","affiliation":[{"name":"Glac Biotech Co., Ltd.  Tainan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leong\u2010Perng","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Kaohsiung Municipal Ta\u2010Tung Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery, Faculty of Medicine, College of Medicine Kaohsiung Medical University Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8589-4805","authenticated-orcid":false,"given":"Chia\u2010Hua","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Cosmetic Science and Institute of Cosmetic Science Chia Nan University of Pharmacy and Science  Tainan 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