{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T11:52:26Z","timestamp":1768564346908,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T00:00:00Z","timestamp":1658188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Treatment of frontal fibrosing alopecia (FFA) is complicated and challenging. In this study, we evaluated the efficacy of combining topical tacrolimus with isotretinoin versus finasteride in patients with FFA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Thirty\u2010one patients with FFA were divided randomly into two groups. Therapeutic regimen of the first group (group A, <jats:italic>n<\/jats:italic>\u00a0=\u00a016) was isotretinoin and tacrolimus (Capsule isotretinoin 20\u2009mg daily and topical tacrolimus 0.1% BD). The second group (group B, <jats:italic>n<\/jats:italic>\u00a0=\u00a015) was given finasteride and tacrolimus (Tablet finasteride 2.5\u00a0mg daily and topical tacrolimus 0.1% BD). Patients were treated and followed up periodically for 12\u2009weeks. Evaluation of the treatment efficacy was based on Patient Global Assessment and Physician Global Assessment scales. Objective evaluation was based on improving the severity of skin lesions by viewing serial images taken from the affected areas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Physician Global Assessment (PGA) was significantly better in the group A as compared with the group B at 4\u2009weeks (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.038). Physician satisfaction in the group A was better than the group B at 12\u2009weeks, but this was not statistically significant (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Patient Global Assessment and patient satisfaction in the group A was better than the group B at 8 and 12\u2009weeks, but it was not statistically significant (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although both therapeutic regimens were effective in the treatment of FFA, treatment with tacrolimus and isotretinoin is significantly more effective than tacrolimus and finasteride.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15232","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T12:20:10Z","timestamp":1657542010000},"page":"613-619","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluating the combined efficacy of oral isotretinoin and topical tacrolimus versus oral finasteride and topical tacrolimus in frontal fibrosing alopecia\u2014A randomized controlled trial"],"prefix":"10.1111","volume":"22","author":[{"given":"Ghasem Rahmatpour","family":"Rokni","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Naser","family":"Emadi","sequence":"additional","affiliation":[{"name":"Skin Research Center, Razi and Imam Khomeini Hospital, Faculty of Medicine Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas","family":"Dabbaghzade","sequence":"additional","affiliation":[{"name":"Pediatrics Infectious Disease Research Center Communicable Disease Institute, Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neda","family":"Jahantigh","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Student Research Committee Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir Mohammad","family":"Beyzaee","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Student Research Committee Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5873-227X","authenticated-orcid":false,"given":"Aseem","family":"Sharma","sequence":"additional","affiliation":[{"name":"Dermatology Department Lokmanya Tilak Municipal Medical College and General Hospital  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidia","family":"Rudnicka","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical University of Warsaw  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8646-1179","authenticated-orcid":false,"given":"Mohamad","family":"Goldust","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Medical Center of the Johannes Gutenberg University  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,19]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-7310(07)70144-8"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.21156"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.12.003"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.12.038"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08861.x"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09965.x"},{"issue":"10","key":"e_1_2_13_8_1","first-page":"988","article-title":"Efficacy of isotretinoin and acitretin in treatment of Frontal fibrosing Alopecia: retrospective analysis of 54 cases","volume":"16","author":"Rakowska A","year":"2017","journal-title":"J Drugs 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