{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T13:46:26Z","timestamp":1783345586692,"version":"3.54.6"},"reference-count":6,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T00:00:00Z","timestamp":1659398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A new hyaluronic acid (HA) formulation was developed based on high molecular weight (MW) compounds used on the surface of the skin while using peptides to stimulate the high MW HA production by fibroblasts and keratinocytes from within the skin layers. Detailed science has been submitted to this journal in a previous publication. This multicenter study aims to validate the science by demonstrating the safety and efficacy of the product in the clinical realm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study evaluated the efficacy and safety of a topical HA serum in facial skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An open\u2010label clinical study was undertaken over 4\u00a0months from November 2021 to March 2022. Participants applied the topical serum twice daily and were provided a gentle cleanser and an SPF 30+ to use in the morning. Follow\u2010up visits were conducted at weeks 2, 4, and 8. At every visit, participants were measured for hydration post 15\u2009minutes of cleansing the skin and post 15\u2009minutes of product application for cumulative skin hydration sensor measurements. Additional procedures included participant assessments and satisfaction, investigator assessments, biopsies, and photography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At each follow\u2010up visit, there was an increase in hydration measurements compared to baseline, in both immediate scores and cumulative long\u2010term scores. At weeks 4 and 8, there was a statistically significant increase in hydration compared to baseline and the prior visit. Participants' assessments progressively increased over 2\u2010, 4\u2010, and 8\u2010week intervals with significantly favorable ratings in all measured parameters. Similarly, investigator assessment grades were statistically significant (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) for decreased fine lines\/wrinkling, crepiness, texture, erythema, and dryness, and increased (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) for moisture\/hydration. Histology revealed increased CD44 staining in 6 of the 7 participants biopsied, denoting increased HA stimulation. In all of the participant biopsies, H&amp;E staining demonstrated improvement in solar elastosis. Photography revealed remarkable improvement in erythema, tone, and texture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The study results demonstrated that the formulation produced significant improvements in immediate and long\u2010term hydration effects on the skin as measured by the skin hydration sensor, \u2018wearifi\u2019 technology, comparison of before and after biopsies, and participant and investigator assessments. This high MW HA formulation produced excellent clinical improvement in skin health and hydration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15241","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T08:35:48Z","timestamp":1657787748000},"page":"3848-3858","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Multicenter evaluation of a topical hyaluronic acid serum"],"prefix":"10.1111","volume":"21","author":[{"given":"Deanne Mraz","family":"Robinson","sequence":"first","affiliation":[{"name":"Modern Dermatology, PLLC  New Haven Connecticut USA"},{"name":"Dermatology Yale  New Haven Connecticut USA"},{"name":"Ideal Image  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janelle","family":"Vega","sequence":"additional","affiliation":[{"name":"Mayoral Dermatology  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie D.","family":"Palm","sequence":"additional","affiliation":[{"name":"Art of Skin MD  Solana Beach California USA"},{"name":"University of California  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4662-7274","authenticated-orcid":false,"given":"Michaela","family":"Bell","sequence":"additional","affiliation":[{"name":"Alastin Skincare, Inc., a Galderma company  Carlsbad California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan D.","family":"Widgerow","sequence":"additional","affiliation":[{"name":"Alastin Skincare, Inc., a Galderma company  Carlsbad California USA"},{"name":"Division Chief, Research, Center for Tissue Engineering, Professor of Plastic Surgery University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Giannini","sequence":"additional","affiliation":[{"name":"DMR Research PLLC  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-47398-6_22"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.342"},{"issue":"3","key":"e_1_2_11_4_1","first-page":"78","article-title":"Hyaluronic acid in inflammation and tissue regeneration","volume":"28","author":"Litwiniuk M","year":"2016","journal-title":"Wounds"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.5b00181"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15027"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.21923"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.15241","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.15241","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.15241","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T18:11:07Z","timestamp":1692468667000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.15241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,2]]},"references-count":6,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1111\/jocd.15241"],"URL":"https:\/\/doi.org\/10.1111\/jocd.15241","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,2]]},"assertion":[{"value":"2022-05-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}