{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:06:01Z","timestamp":1758632761875,"version":"3.40.5"},"reference-count":13,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:00:00Z","timestamp":1659916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Concerns have been raised recently regarding the efficacy and safety of Botulinum toxin type A (BTA) injections following COVID\u201019 vaccination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess the influence of BNT162b2 mRNA vaccine on the safety and efficacy of BTA injections performed for aesthetic indications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study followed patients undergoing periodic BTA treatments who completed two doses of BNT162b2 vaccine. The latency between BTA injections before and after getting vaccinated was assessed for all study participants. Efficacy and longevity of BTA was reflected and evaluated by the latency between BTA injections. Patients were longitudinally monitored for the development of adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010five patients were eligible for inclusion in the current study. The mean (standard deviation [SD]) age of patients was 48.3 (8.9) years and 40 (88.9%) patients were females. The mean (SD) number of pre\u2010 and post\u2010COVID\u201019 vaccination BTA injections was 5.1 (2.6) and 3.1 (0.4), respectively. The average (SD) interval between BTA injections after COVID\u201019 vaccination (96.0 [12.3] days) was significantly shorter than before it (118.6 [22.7]; <jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001). No severe BTA\u2010associated adverse events were registered after the administration of BNT162b2 vaccine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings indicate that BTA might be less effective after COVID\u201019 vaccination. Further research is required to delineate the pathomechanism underlying this observation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15251","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T08:01:28Z","timestamp":1658476888000},"page":"3663-3666","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Influence of <scp>COVID<\/scp>\u201019 <scp>mRNA<\/scp> vaccination on the efficacy and safety of Botulinum toxin type A injections"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5642-6508","authenticated-orcid":false,"given":"Shirin","family":"Hamed Azzam","sequence":"first","affiliation":[{"name":"Oculoplastic Clinic Estemed Medical Center  Kfar Kanna Israel"},{"name":"Ophthalmology Department Baruch Padeh Medical Center  Poriya Israel"},{"name":"Azrieli Faculty of Medicine Bar\u2010Ilan University  Safed Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abed","family":"mukari","sequence":"additional","affiliation":[{"name":"Oculoplastic Clinic Estemed Medical Center  Kfar Kanna Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mira","family":"Hamed","sequence":"additional","affiliation":[{"name":"Dermatology Department Emek Medical Center  Afula Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalaf","family":"Kridin","sequence":"additional","affiliation":[{"name":"Azrieli Faculty of Medicine Bar\u2010Ilan University  Safed Israel"},{"name":"Unit of Dermatology and Skin Research Laboratory Baruch Padeh Poria Medical Center  Poriya Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMOA2101765"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMOA2022483"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMOA2034577"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMOA2035389"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.5114\/ADA.2019.82795"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ENE.14569"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000027787"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00266-020-01684-4"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ASJ\/SJU105"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/JOCD.13897"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.MEDIDD.2020.100042"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000010659"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JNEUROIM.2011.10.005"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.15251","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.15251","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.15251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T18:13:05Z","timestamp":1692468785000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.15251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,8]]},"references-count":13,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1111\/jocd.15251"],"URL":"https:\/\/doi.org\/10.1111\/jocd.15251","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"type":"print","value":"1473-2130"},{"type":"electronic","value":"1473-2165"}],"subject":[],"published":{"date-parts":[[2022,8,8]]},"assertion":[{"value":"2022-05-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}