{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T22:57:39Z","timestamp":1776380259031,"version":"3.51.2"},"reference-count":47,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>COVID\u201019 vaccines are currently the most effective interventions in controlling and preventing severe disease progression. Dermatologic reactions to COVID\u201019 vaccinations may be rare among clinical trial participants. However, since global mass vaccination became a reality, these adverse effects may become more widespread, and different skin reactions would arise.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To systematically review the cutaneous adverse reactions in cases subject to vaccines for COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched the PubMed, SCOPUS, Web of Science, and Embase databases, identifying the relevant records and including the eligible observational ones. After assessing the methodological quality of the included studies, we qualitatively and quantitatively synthesized the data regarding the cutaneous side effects experienced by those in the studies' population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 36 studies were included in our systematic review, with the majority being cross\u2010sectional. We found that pain, erythema, and swelling were the most common local side effects, while different types of rashes, urticaria, and angioedema were the most non\u2010local. Few cases also reported experiencing flare\u2010ups of their underlying diseases or developing newly\u2010onset diseases of various etiologies. Our meta\u2010analyses also found that while viral vector\u2010based vaccines are, though insignificantly, safer in injection site complaints, individuals who received mRNA vaccines developed significantly fewer non\u2010local cutaneous adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Cutaneous reactions to the COVID\u201019 vaccines are similar to common cutaneous drug eruptions and COVID\u201019 cutaneous manifestations. However, we believe that further high\u2010quality research is needed to assess better how and why cutaneous reactions occur in different vaccines.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15261","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T13:55:16Z","timestamp":1658411716000},"page":"3636-3650","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Cutaneous adverse reactions following COVID\u201019 vaccinations: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7319-000X","authenticated-orcid":false,"given":"Mohammad","family":"Shafie'ei","sequence":"first","affiliation":[{"name":"Faculty of Medicine Kerman University of Medical Sciences  Kerman 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