{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:54:33Z","timestamp":1791489273554,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T00:00:00Z","timestamp":1661126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T00:00:00Z","timestamp":1661126400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Psoriasis (PsO) is a systemic autoimmune disease. Many pro\u2010inflammatory and anti\u2010inflammatory biomarkers have been associated with the pathogenetic process of psoriasis. IL\u201035 act as an anti\u2010inflammatory cytokine through downregulation of TH\u201017 cell development and cytokine production. So, IL\u201035 might be utilized as potential future therapeutic agent for psoriasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate the association between inflammatory (IL\u201017, TNF\u2010\u03b1, IFN\u2010\u03b3) and anti\u2010inflammatory cytokines (IL\u201035, TGF\u2010\u03b2) in psoriasis patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>A case\u2013control study enrolled two groups: (Group I: 40 patients with psoriasis) and (Group II: 40 healthy age and sex\u2010matched subjects). Full history was taken from all cases along with full dermatologic examination. The assessment of psoriasis severity was conducted by using PASI score. Assessment of inflammatory (IL\u201017, TNF\u2010\u03b1, IFN\u2010\u03b3) and anti\u2010inflammatory cytokines (IL\u201035, TGF\u2010\u03b2) was performed by using ELISA technique.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There was a statistically significant increase of mean level of TNF\u2010\u03b1, IL\u201017, and IFN\u2010\u03b3 among psoriasis cases in comparison with controls. The mean level of TGF\u2010\u03b2 and IL\u201035 was statistically significantly reduced among the psoriasis cases in comparison with controls. TNF\u2010\u03b1, IL\u201017, and IFN\u2010\u03b3 showed a significant strong positive association in between and statistically significant strong negative relationship with IL\u201035 and TGF\u2010\u03b2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IL\u201035 has a significant role in the pathogenetic process of PsO, and it serves as a potential future therapeutic agent for psoriasis. The current results could be used as a clue for the utilization of inflammatory (IL\u201017, TNF\u2010\u03b1, IFN\u2010\u03b3) versus anti\u2010inflammatory cytokines (IL\u201035, TGF\u2010\u03b2) in psoriasis patients as a diagnostic biomarker for severity of cases with psoriasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.15262","type":"journal-article","created":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T04:54:44Z","timestamp":1658552084000},"page":"6302-6307","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Pro\u2010inflammatory versus anti\u2010inflammatory cytokines in psoriatic patients (case\u2013control study)"],"prefix":"10.1111","volume":"21","author":[{"given":"Amaal Mohamed","family":"Elbana","sequence":"first","affiliation":[{"name":"Damietta Dermatology and Leprosy Hospital, Ministry of Health and Population  Damietta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emadeldin","family":"Elgamal","sequence":"additional","affiliation":[{"name":"Dermatology, Venereology and Andrology, Faculty of Medicine Al\u2010Azhar University  Damietta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama","family":"Hashim","sequence":"additional","affiliation":[{"name":"Dermatology, Venereology and Andrology, Faculty of Medicine Al\u2010Azhar University  Damietta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek Mostafa","family":"Emran","sequence":"additional","affiliation":[{"name":"Clinical Pathology, Faculty of Medicine Al\u2010Azhar University  Damietta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr Abdelhady","family":"Alkhrsawy","sequence":"additional","affiliation":[{"name":"Clinical Pathology, Faculty of Medicine Al\u2010Azhar University  Damietta 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