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Searches were conducted in different databases. We included studies that used a randomized control and self\u2010control design and were carried out in humans. Articles published in English and Portuguese were screened, with no time limit regarding the year of publication. The methodological quality of the studies was assessed using the Cochrane Rob2 scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 381 articles, seven were considered eligible for inclusion. After applying the Cochrane Rob2 scale, five studies were included in the final sample. Most studies showed significant results for cryolipolysis in reducing localized fat. The incorporation of a dietary program into the treatment was shown to contribute to a significant improvement in the lipid profile and liver enzymes, which does not happen when cryolipolysis is applied in isolation. Rare adverse effects have been identified, but never persisting beyond a month.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cryolipolysis is an effective technique for reducing localized fat, safe, and well tolerated, with most participants satisfied at the end of the treatment. However, more randomized controlled studies should be carried out, since there is a limited number of articles with good methodological quality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15265","type":"journal-article","created":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T09:29:10Z","timestamp":1658568550000},"page":"4122-4132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Application of cryolipolysis in adipose tissue: A systematic review"],"prefix":"10.1111","volume":"21","author":[{"given":"Leonor","family":"Resende","sequence":"first","affiliation":[{"name":"Department of Clinical Analysis, School of Health Polytechnic Institute of Porto  Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreia","family":"Noites","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, School of Health Polytechnic Institute of Porto  Porto Portugal"},{"name":"Center for Rehabilitation Research (CIR) \u2013 Human Movement System (Re) habilitation Polytechnic Institute of Porto  Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Amorim","sequence":"additional","affiliation":[{"name":"Department of Clinical Analysis, School of Health Polytechnic Institute of Porto  Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2009.12.009"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2020.105737"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6052194"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-036684"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-020-01865-1"},{"key":"e_1_2_11_7_1","first-page":"201","article-title":"Cryolipolysis for noninvasive body contouring: clinical efficacy and patient satisfaction","volume":"7","author":"Krueger N","year":"2014","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14850"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12994"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0242782"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/asjof\/ojaa010"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S146258"},{"key":"e_1_2_11_13_1","unstructured":"VendraminiRTerapias utilizadas em procedimentos do profissional da farm\u00e1cia est\u00e9tica.2018."},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23250"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12386"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjpt.2019.07.005"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22475"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000415"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22207"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.233"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjw250"},{"key":"e_1_2_11_24_1","unstructured":"ZELTIQ.User Manual CoolSculpting System (ZELTIQ Breeze System).2019."},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3889\/oamjms.2019.318"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22302"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12495"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.21145"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/81.6.1298"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00574.2009"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.4103\/1735-1995.187269"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jada.2011.10.007"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22674"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5276528"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20850"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000003433"},{"key":"e_1_2_11_37_1","unstructured":"OliveiraEES PereiraMM.O uso da criolip\u00f3lise na redu\u00e7\u00e3o de gordura: uma revis\u00e3o da literatura.2020."},{"key":"e_1_2_11_38_1","unstructured":"Borges FdosS ScorzaFA.Fundamentos da Criolip\u00f3lise. 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