{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:17:12Z","timestamp":1791487032866,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/Objectives<\/jats:title>\n                    <jats:p>The diagnosis of psoriasis is usually established on clinical grounds but there is lacking of such diagnostic tools to stratify its severity. Psoriasis is a chronic inflammatory disease of skin, nails, and joints. Dermoscopy represent a novel diagnostic tool to diagnose and assess psoriasis severity. The main purpose of this study is to assess the value of dermoscopy associated with serum level of high\u2010mobility group box\u20101 level (HMGB\u20101) in the diagnosis and stratification of psoriasis severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study included 60 Egyptians subdivided into two equal groups, psoriatic patients, and controls. All patients were subjected first to dermoscopic examination, and then we evaluated the serum levels of HMGB\u20101 among all studied groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The level of HMGB\u20101 increased in psoriatic patients than controls. There was significant difference between patients and controls in the serum levels of HMGB \u20101. There were also a positive significant correlation between HMGB\u20101 and different stages of disease severity. There were also significant correlations between HMGB\u20101 and specific dermoscopic findings like vascular pattern and vascular number, erythema grades as well as types of scales (Fine, coarse) and (Fine, thick).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Dermoscopy and HMGB\u20101 can be considered as a combined novel diagnostic tool for psoriasis severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.15282","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T10:38:40Z","timestamp":1659091120000},"page":"6336-6342","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Involvement of high\u2010mobility group box\u20101 and Dermoscopy in diagnosis of psoriasis severity"],"prefix":"10.1111","volume":"21","author":[{"given":"Noha Ezzat","family":"Mohamad","sequence":"first","affiliation":[{"name":"Department of Dermatology, STDs and Andrology, Faculty of Medicine Fayoum University  Fayoum Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noha","family":"Hashem","sequence":"additional","affiliation":[{"name":"Department of Dermatology, STDs and Andrology, Faculty of Medicine Fayoum University  Fayoum Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar","family":"Eltahlawy","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enas","family":"Gomaa","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Faculty of Medicine Fayoum University  Fayoum 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