{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:15:42Z","timestamp":1791486942502,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n E\u2010cadherin is a classic cadherin that mediates keratinocyte adhesion.<\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n To assess the tissue expression of E\u2010cadherin and its proteolytic serum fragment (soluble E\u2010cadherin) in pemphigus vulgaris (PV) before and after clinical remission compared with controls.<\/jats:p>\n <\/jats:sec>\n \n Patients<\/jats:title>\n Thirty\u2010seven PV patients and thirty controls were enrolled. Pemphigus disease area index (PDAI) was calculated for patients at baseline and after remission. Punch biopsy specimens were taken from patients before, and after remission, and from controls for assessment of tissue E\u2010cadherin by immunofluorescence. Similarly, serum samples were collected for assessment of serum soluble E\u2010cadherin by ELISA.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Presence, intensity, and mean intensity of tissue E\u2010cadherin were significantly reduced in PV patients before treatment compared with controls (\n p<\/jats:italic>\n \u00a0<\u20090.001). Detected E\u2010cadherin showed mainly a basal and suprabasal distribution with cell surface and a cytoplasmic expression. Serum E\u2010cadherin was significantly higher in patients before treatment compared with controls (\n p<\/jats:italic>\n \u00a0=\u20090.006). With remission, tissue E\u2010cadherin presence, intensity, mean intensity, and serum E\u2010cadherin showed statistically significant improvement (\n p<\/jats:italic>\n \u00a0=\u20090.003, <0.001, <0.001, and 0.003 respectively). Tissue E\u2010cadherin presence and serum E\u2010cadherin level reached values equivalent to the controls (\n p<\/jats:italic>\n \u00a0=\u20090.49 and 0.44, respectively).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Disruption of tissue E\u2010cadherin and upregulation of serum soluble E\u2010cadherin can contribute to the pathogenesis of PV. Clinical remission of PV is associated with normalization of tissue and serum E\u2010cadherin.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jocd.15284","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T03:22:29Z","timestamp":1659324149000},"page":"6343-6350","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Assessment of tissue E\u2010cadherin and its proteolytic serum fragment in pemphigus vulgaris before and after remission: A\u00a0case\u2013control study"],"prefix":"10.1111","volume":"21","author":[{"given":"Randa Mohammed","family":"Youssef","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9487-8708","authenticated-orcid":false,"given":"Marwah Adly","family":"Saleh","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona\u00a0Mostafa","family":"Korany","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab A.","family":"Nour","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9208-2458","authenticated-orcid":false,"given":"Mona","family":"El\u2010Kalioby","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/jomfp.JOMFP_143_17"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701260"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3431"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-015-1977-0"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3136"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb00720.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.01.012"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.72"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.156386"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2018.11.002"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057587"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI64413"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000051540"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1994.tb03294.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/21.8.1948"},{"key":"e_1_2_11_17_1","volume-title":"Soluble E\u2010cadherin as a microenvironmental factor which enhances tumor progression","author":"Patil PU","year":"2015"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12455"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M309000200"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-39401-0"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2012.702811"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.15284","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.15284","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.15284","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:20:25Z","timestamp":1791483625000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.15284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,2]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1111\/jocd.15284"],"URL":"https:\/\/doi.org\/10.1111\/jocd.15284","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,2]]},"assertion":[{"value":"2022-02-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}