{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:50:22Z","timestamp":1791492622848,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Psoriasis Vulgaris is a common immune\u2010mediated skin disease. Its high prevalence, disability, chronicity, disfiguration, and associated comorbidities make it a challenge for physicians. Topical agents remain the mainstay of treatment for patients with mild to moderate psoriasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the efficacy and tolerability of topical methotrexate 1% gel (MTX) versus topical calcipotriol 0.005% cream (CPL) in the treatment of localized plaque psoriasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective comparative study included 40 patients with localized plaque psoriasis instructed to apply MTX to one side (group A) and CPL to the other side lesions (group B) twice daily for 12\u2009weeks. Clinical and dermoscopic evaluations before, weekly during and after 3\u00a0months of treatment were done. The immunohistopathological assessment was done for skin biopsies from 10 patients in each group before and after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At the end of 12\u2009weeks, there was marked\u2010complete improvement in 97.5% of group A lesions treated with MTX 1% gel compared with 37.5% of group B lesions treated with calcipotriol 0.005% cream (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u20090.001). There was a very high statistically significant improvement in erythema that was cleared totally in 67.5% vs 22.5%, scaling in 75% vs 17.5%, and infiltration in 72.5% vs 27.5% in group A vs B, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u20090.001). These results were confirmed by dermoscopic and immunohistopathological findings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Methotrexate 1% gel is a marvelous promising well\u2010tolerated effective topical agent that can be used safely in the treatment of localized plaque psoriasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.15285","type":"journal-article","created":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T16:58:18Z","timestamp":1659200298000},"page":"5779-5789","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical, dermoscopic, and histopathologic evaluation of topical methotrexate 1% hydrogel versus topical Calcipotriol 0.005% cream in the treatment of plaque psoriasis"],"prefix":"10.1111","volume":"21","author":[{"given":"Maha A.","family":"El Gayar","sequence":"first","affiliation":[{"name":"Department of Dermatology, Andrology &amp; STDs, Faculty of Medicine Mansoura University  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina","family":"Atwa","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine Mansoura University  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Germeen","family":"Girgis","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy Mansoura University  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamees","family":"Marie","sequence":"additional","affiliation":[{"name":"Department of Dermatology Damietta Specialized Hospital  Damietta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12339"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.51847\/g6sNNo5abA"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4006"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.15628"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.286"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2006.02911.x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.02.077"},{"issue":"6","key":"e_1_2_12_9_1","first-page":"4974","article-title":"Imaging techniques in the diagnosis and monitoring of psoriasis","volume":"18","author":"Grajdeanu I\u2010A","year":"2019","journal-title":"Exp Ther Med"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1994.tb01073.x"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/0377-4929.94857"},{"key":"e_1_2_12_12_1","first-page":"28","article-title":"Comparative clinical assessment of effectiveness and safety of calcitriol and Calcipotriol in mild plaque psoriasis","volume":"3","author":"Mahajan H","year":"2020","journal-title":"Int J Clin Dermatol"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.32007\/jfacmedbagdad.5211047"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/soilsystems5030047"},{"key":"e_1_2_12_15_1","first-page":"495","volume-title":"Psoriasis. 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