{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:49:15Z","timestamp":1791496155096,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T00:00:00Z","timestamp":1663545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T00:00:00Z","timestamp":1663545600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773347"],"award-info":[{"award-number":["81773347"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The carbon dioxide (CO\n                      <jats:sub>2<\/jats:sub>\n                      ) fractional laser resurfacing has become one of the hottest therapies for dermatoses. However, complications such as skin swelling, prolonged erythema, post\u2010inflammatory hyperpigmentation, and scar formation remain. Low\u2010level laser (LLL) therapy is accepted to promote skin wound healing and regeneration, decrease inflammation and pain, and modulate immunoreaction with low\u2010dose laser of different wavelength. 532\u2009nm laser therapy is commonly used to remove pigmented spots and to tender skin, but not utilized in wound care.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      We aimed to determine the efficacy of the low\u2010level 532\u2009nm green laser in wound healing after CO\n                      <jats:sub>2<\/jats:sub>\n                      fractional laser.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Six adult male mice (C57BL\/6, 8\u2009weeks old) were prepared for animal experiments. The dorsum of each mouse was divided into four parts that, respectively, received designed treatments, as controlled (group Ctrl), 532\u2009nm LLL\u2010treated (group GL), CO\n                      <jats:sub>2<\/jats:sub>\n                      fractional laser\u2010treated (group FL), and CO\n                      <jats:sub>2<\/jats:sub>\n                      fractional laser followed by three times 532\u2009nm LLL\u2010treated (group FG). Hematoxylin\u2013eosin staining (H&amp;E), Masson\u2010trichrome staining, CD31 immunohistochemical staining were performed to evaluate the efficacy of wound healing after treated by different irradiations. Western blotting was used to detect the expression of related proteins. Mouse skin fibroblasts (MSFs) were treated with LLL using a wavelength of 532\u2009nm once. Cellular responses were observed and analyzed after 48\u2009hours. Cell viability and migration of different groups were assessed by scratch and the Cell Counting Kit\u20108 (CCK8) assays, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Collagen remodeling and epidermis thickness were significantly enhanced in group FG than that in group FL in morphology. Besides, CD31 immunohistochemical staining indicated prominently increased angiogenesis in both groups FL and FG than non\u2010irradiation group. The expression of extracellular matrix (ECM)\u2010related protein (Col1, Col3 and MMP1) showed a remarkable improvement in wound healing in group FG than that in group FL. Irradiated MSFs showed a better migration ability compared with non\u2010irradiated controls. LLL enhanced the secretion function of MSFs on Collagen I and III.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Low\u2010level green laser promotes wound healing after CO\n                      <jats:sub>2<\/jats:sub>\n                      fractional laser by improving the integrity of skin barrier and allowing for scarless healing. Therefore, low\u2010level green laser therapy might serve as a sequential therapy of invasive laser surgery to ensure a better wound care.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.15298","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T12:27:20Z","timestamp":1660134440000},"page":"5696-5703","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Low\u2010level green laser promotes wound healing after carbon dioxide fractional laser therapy"],"prefix":"10.1111","volume":"21","author":[{"given":"Chengchen","family":"Gong","sequence":"first","affiliation":[{"name":"Department of Dermatology, Shanghai East Hospital Tongji University School of Medicine  Shanghai 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