{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:16:49Z","timestamp":1791487009981,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Psoriasis is a skin disorder mainly mediated by T helper (Th)\u20101 and Th\u201017 cells. Recently, high serum immunoglobulin (Ig)\u2010E levels were detected in psoriatic patients. The etiopathogenesis of IgE overproduction in psoriatic patients is still unknown, but IL\u201017 has been suggested to be responsible for this abnormality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare levels of IgE and IL\u201017 in the sera of patients with chronic plaque psoriasis (CPP) to healthy subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study included 40 patients with CPP and 40 age\u2010 and sex\u2010matched healthy individuals. Serum IgE and IL\u201017 concentrations were measured using the enzyme\u2010linked immunosorbent assay (ELISA) technique.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Levels of IgE and IL\u201017 were significantly higher in the sera of psoriatic patients than in controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.001 and 0.024, respectively). Psoriatic patients with abnormally high serum IgE levels had higher serum IL\u201017 levels than those with normal serum IgE levels, but the difference was statistically insignificant (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.080). Furthermore, no significant correlation was found between serum IgE and IL\u201017 concentrations in psoriatic patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.385).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>It is possible that IgE and IL\u201017 interact in psoriasis pathogenesis; however, this was not evident in the current study, possibly due to the small sample size. Therefore, other potential causes of elevated IgE levels in psoriatic patients should be investigated. Moreover, the interaction between IgE and IL\u201017 should be investigated in patients with other clinical variants of psoriasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.15299","type":"journal-article","created":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T01:25:16Z","timestamp":1660267516000},"page":"6377-6384","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Serum immunoglobulin E and Interleukin\u201017 levels in patients with chronic plaque psoriasis: A\n                    <scp>case\u2013control<\/scp>\n                    study"],"prefix":"10.1111","volume":"21","author":[{"given":"Amany A.","family":"Nassar","sequence":"first","affiliation":[{"name":"Department of Dermatology Venereology and Andrology, Faculty of Medicine, Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noha M.","family":"Bakr","sequence":"additional","affiliation":[{"name":"Biochemistry Department National Research Centre  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enas H. I.","family":"Elyousefi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Andrology, Faculty of Medicine, Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basma M.","family":"Elkholy","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Andrology, Faculty of Medicine, Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5490-9672","authenticated-orcid":false,"given":"Manal M.","family":"Fawzy","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Andrology, Faculty of Medicine, Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19169"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20061475"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890701449354"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14459"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.EWX.0000450678.40084.23"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.15226\/2378-1726\/4\/4\/00163"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.5455\/msm.2020.32.105-107"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.175"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11099.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.194"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/JEWD.JEWD_29_19"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/112604"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000250839"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1265"},{"issue":"7","key":"e_1_2_10_16_1","first-page":"515","article-title":"Total serum IgE concentration in patients with psoriasis: a case\u2010control study","volume":"52","author":"Lajevardi V","year":"2014","journal-title":"Acta Med Iran"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12943"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00998.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-50899-9_36"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1181"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14046720"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015550050500077"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-014-1322-0"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7420823"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/467541"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2009.03704.x"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.15299","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.15299","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.15299","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:22:38Z","timestamp":1791483758000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.15299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,2]]},"references-count":25,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1111\/jocd.15299"],"URL":"https:\/\/doi.org\/10.1111\/jocd.15299","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,2]]},"assertion":[{"value":"2022-06-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}