{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:49:49Z","timestamp":1791496189871,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,9,4]],"date-time":"2022-09-04T00:00:00Z","timestamp":1662249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,9,4]],"date-time":"2022-09-04T00:00:00Z","timestamp":1662249600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cetirizine, a widely used agent for allergic disorders, has recently been topically used for treating androgenetic alopecia (AGA). We aimed to summarize the current evidence regarding the effectiveness and safety of topical cetirizine for treating AGA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched Ovid MEDLINE, Embase, and Cochrane Central Register of Controlled Trials. We included both randomized controlled trials (RCTs) and non\u2010randomized clinical trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>We initially identified 102 records, of which, we included two RCTs and one non\u2010randomized clinical trial, which were of moderate\u2010to\u2010high risk of bias. All included trials used 1% topical cetirizine as the intervention with various regimens. Topical cetirizine was likely to be more effective than a placebo for treating AGA. In comparison with topical minoxidil, topical cetirizine appears to be less effective for improving total and vellus hair density, but it might have a longer\u2010lasting effect. Further, cetirizine might be as effective as minoxidil in improving hair diameter.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>One percent topical cetirizine may serve as a choice for treating AGA, especially for patients with a negative response to topical minoxidil. In order to fully understand the role of topical cetirizine for AGA, additional well\u2010designed RCTs are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.15309","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T09:29:43Z","timestamp":1660728583000},"page":"5519-5526","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Topical cetirizine for treating androgenetic alopecia: A\u00a0systematic review"],"prefix":"10.1111","volume":"21","author":[{"given":"Xiaomei","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Dermatology West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Dermatology West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Yang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Geriatrics West China Hospital, Sichuan University  Chengdu China"},{"name":"Chinese Cochrane Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2021.2196"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13835"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2007.03.004"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1951.tb31971.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2003.05565.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000011379"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.117426"},{"issue":"4","key":"e_1_2_11_9_1","first-page":"457","article-title":"A systematic review of topical finasteride in the treatment of androgenetic alopecia in men and women","volume":"17","author":"Lee SW","year":"2018","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-016-0629-5"},{"issue":"4","key":"e_1_2_11_11_1","first-page":"27","article-title":"Herbal medicines for treatment of androgenic alopecia","volume":"26","author":"Asnaashari S","year":"2020","journal-title":"Altern Ther Health 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