{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:13:49Z","timestamp":1791486829739,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acanthosis nigricans (AN) is an asymptomatic skin condition linked to several underlying systemic conditions. Chemerin is an adipokine that increases during inflammatory disorders such as metabolic syndrome (MetS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This case\u2013control study investigates the link between AN and the underlying MetS and serum levels of chemerin in individuals with obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Methods<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010five adults with AN and obesity (body mass index [BMI]\u2009&gt;\u200930\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ), 25 adults with obesity but no AN, and 25 healthy controls (BMI\u2009&lt;\u200930\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) had their lipid profiles and serum chemerin concentrations examined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The neck (80.0%) and axilla (68.0%) were the most common sites of AN. In participants with obesity, either alone or with AN, serum chemerin concentrations were significantly higher than in the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u20090.001). Participants with obesity and AN had significantly higher levels of cholesterol, triglycerides (TG), low\u2010density lipoprotein cholesterol (LDL\u2010c), and serum chemerin levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u20090.001), and significantly lower high\u2010density lipoprotein cholesterol (HDL\u2010c) levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u20090.001) when compared to participants with obesity alone. All participants with obesity and AN (100%) and 88% of those with obesity alone had MetS. Logistic regression revealed that systolic blood pressure &gt;130\u2009mmHg, diastolic blood pressure &gt;85\u2009mmHg, waist circumference &gt;90\u2009cm, TG &gt;150\u2009mg\/dl, HDL\u2010c &lt;45\u2009mg\/dl, fasting blood glucose &gt;100\u2009mg\/dl, and serum chemerin &gt;300\u2009ng\/ml were significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u20090.05) risk factors for AN.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Acanthosis nigricans is a non\u2010invasive and reliable sign of the underlying MetS and increased serum chemerin levels among individuals with obesity.<\/jats:p>\n                  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