{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:49:12Z","timestamp":1791492552167,"version":"4.3.4"},"reference-count":18,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Androgenetic alopecia (AGA) is a common chronic dermatological illness that affects both men and women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess and compare dermoscopically the impact of a combination of topical minoxidil solution (5%) and topical spironolactone solution (5%) in treating AGA in both sexes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      One hundred and twenty patients diagnosed with AGA were divided into three groups; each group is composed of 40 patients. Group A (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a040) were treated with a 5% topical minoxidil solution, group B (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a040) were treated with a 5% topical spironolactone solution, and group C (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a040) were treated with a 5% topical minoxidil and spironolactone combination.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Following the initiation of treatment and at 6\u2009weeks (midterm), reduction in all dermoscopic features was observed in all groups; however, it was not statistically significant except for vellus hair reduction (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.033). On the contrary, upright regrowing hairs were insignificantly increased in all groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a01.088). The pattern of dermoscopic features remained to insignificantly decrease toward the end of 12\u2009weeks treatment (full term) in all studied groups except for vellus hair that showed further significant reduction toward the end of the study (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.011).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both spironolactone as a 5% topical solution and minoxidil as a 5% topical solution might be used safely in a twice\u2010daily dosage to treat AGA in both genders. Furthermore, combining them in a single topical dose form can boost efficacy and yield greater advantages.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.15328","type":"journal-article","created":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T01:48:45Z","timestamp":1661824125000},"page":"5790-5799","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Dermoscopic evaluation of the efficacy of combination of topical spironolactone 5% and minoxidil 5% solutions in the treatment of androgenetic alopecia: A cross sectional\u2010comparative study"],"prefix":"10.1111","volume":"21","author":[{"given":"Amr M.","family":"Ammar","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology, Faculty of Medicine Al\u2010Azhar University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed R.","family":"Elshahid","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology, Faculty of Medicine Al\u2010Azhar University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamdy A.","family":"Abdel\u2010Dayem","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine Al\u2010Azhar University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed A.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology, Faculty of Medicine Al\u2010Azhar University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7541-5241","authenticated-orcid":false,"given":"Mohamed L.","family":"Elsaie","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Medical and Clinical Research Institute National Research Centre  Cairo 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