{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T12:57:15Z","timestamp":1774184235713,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T00:00:00Z","timestamp":1665360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Periorbital dark circles (PDC) is one of the most common cosmetic issues in today's society. Only moderate degree of improvement has been achieved by various available treatment options. The present study aimed to compare the clinical efficacy of carboxytherapy and fractional CO<jats:sub>2<\/jats:sub> laser therapy in the management of PDC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this split face study, 30 patients with bilateral PDC aged between 23 and 52\u2009years were recruited who underwent carboxytherapy (<jats:italic>n<\/jats:italic>\u00a0=\u00a030) on PDC of one side of the face and fractional CO<jats:sub>2<\/jats:sub> laser therapy (<jats:italic>n<\/jats:italic>\u00a0=\u00a030) on the PDC of other side. The entire treatment comprised of four sessions of each therapy with an interval of 2\u2009weeks each time. The assessment was based on both subjective methods (patients' satisfaction and physician's judgment) and objective method (based on digital standard photographs). The degree of improvement from the patient's point of view (patient satisfaction) and physician's point of view (physician satisfaction) was assessed in different therapy sessions in comparison with the improvement after first session.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 30 patients with mean age of 38.22\u2009\u00b1\u20098.3\u2009years. The mean disease duration was 45\u2009\u00b1\u200912.3\u00a0months. After the second therapy session, patients' satisfaction was remarkably better in the fractional CO<jats:sub>2<\/jats:sub> laser therapy group than the carboxytherapy group, over the time. According to the physician satisfaction, the improvement rate was higher after the second and sixth weeks in the fractional CO<jats:sub>2<\/jats:sub> laser therapy group than the carboxytherapy group; whereas in other sessions, there were no statistically significant differences. There were no significant side effects observed in either group post\u2010treatment each time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fractional CO<jats:sub>2<\/jats:sub> laser therapy is a better option to treat PDC than carboxytherapy. Also, mild side effects (including erythema, pain, and discomfort) were reported in both groups; with no significant difference between the groups.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15337","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T08:03:09Z","timestamp":1662451389000},"page":"512-516","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Comparison of the efficacy of carboxytherapy versus fractional <scp>CO<sub>2<\/sub><\/scp> laser therapy for the treatment of periorbital dark circles: A randomized clinical trial"],"prefix":"10.1111","volume":"22","author":[{"given":"Hooman","family":"Zaheri","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Student Research Committee Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir Mohammad","family":"Beyzaee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghasem Rahmatpour","family":"Rokni","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9455-4025","authenticated-orcid":false,"given":"Anant","family":"Patil","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Dr. DY Patil Medical College  Navi Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masoud","family":"Golpour","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Mazandaran University of Medical Sciences  Sari 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