{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:58:56Z","timestamp":1785549536102,"version":"3.56.0"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Acne is a significant problem in young people. At present, most acne treatment products are topically applied cosmetics, whose efficacy is limited by the stratum corneum. The dissolving microneedle technique can effectively deliver drug molecules into the body. In this study, dissolving microneedles containing anti\u2010acne ingredients were tested for human efficacy and safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a 28\u2010day clinical efficacy and safety trial on 30 individuals with visible facial acne. During the trial, anti\u2010acne microneedle (AA\u2010DMN) patches were applied to designated skin areas once daily for 28 consecutive days. Skin pigmentation was measured using a Courage + Khazaka skin melanin and hemoglobin test probe Mexameter MX18. Acne volume was measured using a Canfieldsci skin rapid optical imaging system PRIMOS. In addition, skin irritation was evaluated via self\u2010report and dermatologist's examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The AA\u2010DMN patches showed good efficacy including improvement of skin pigmentation and reduced acne volume. Acne volume was reduced by 12.34% after 3\u2009days of patch use and further reduced by 10.01% after 7 continuous days of use. After 28\u2009days of treatment, skin melanin decreased by 5.88% and heme decreased by 7.83%. No adverse reactions were observed in any of the participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Anti\u2010acne microneedle patches showed an excellent effect in reducing acne and post\u2010inflammatory hyperpigmentation (PIH), without adverse skin reactions. The novel AA\u2010DMN patch is a safe and effective anti\u2010acne treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15352","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T07:24:49Z","timestamp":1662362689000},"page":"6913-6919","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Acne and its post\u2010inflammatory hyperpigmentation treatment by applying anti\u2010acne dissolving microneedle patches"],"prefix":"10.1111","volume":"21","author":[{"given":"Meiling","family":"Tai","sequence":"first","affiliation":[{"name":"Infinitus (China) Company Ltd  Jiangmen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenggong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Organic Functional Materials and Applied Technology Institute  SuZhou 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