{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:15:55Z","timestamp":1790878555222,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>During aging, human skin is facing hyperpigmentation disorders: senile <jats:italic>lentigo<\/jats:italic> (chronobiologic aging) leads to loss of melanogenesis' control while solar <jats:italic>lentigo<\/jats:italic> (UV exposure) promotes an increase of oxidized proteins, melanogenesis, and lipofuscin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>Stromal\u2010cell\u2010derived\u2010factor\u20101 (SDF\u20101) was identified as key regulator of hyperpigmentation and its expression is reduced in senescent fibroblasts, highlighting this protein as new target for skin hyperpigmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials<\/jats:title><jats:p>We developed two skin explant models mimicking of senile and solar <jats:italic>lentigo,<\/jats:italic> based on H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> systemic treatment and UV irradiation, respectively. We evaluated <jats:italic>Himanthalia elongata<\/jats:italic> extract (HEX) on these models after 5\u2009days of treatment and analyzed SDF\u20101 expression and skin pigmentation. For solar <jats:italic>lentigo<\/jats:italic>, we also analyzed oxidized proteins and lipofuscin accumulation. Finally, we evaluated HEX in vivo on nearly 100 multi ethnicities' volunteers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SDF\u20101 expression decreased in senile <jats:italic>lentigo<\/jats:italic> model, associated with hyperpigmentation. HEX application restored SDF\u20101 expression, leading to skin pigmentation decrease. For solar <jats:italic>lentigo<\/jats:italic>, we showed an impact of UVs on SDF\u20101 expression linked to hyperpigmentation, while the application of HEX restored SDF\u20101 expression and reduced skin pigmentation. On same model, HEX reduced oxidized proteins quantity and lipofuscin which increased after UV exposure. Clinically, HEX reduced dark spot pigmentation on Caucasian volunteers' hands and on Asian and African volunteers' face after 28\u2009days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>We have developed ex vivo models mimetic of senile and solar <jats:italic>lentigo<\/jats:italic> and showed for a very first time that SDF\u20101 can be also a key regulator for UV\u2010induced hyperpigmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our ex vivo and clinical studies highlighted the power of HEX with strong reduction of dark spots regardless of volunteers' ethnicities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15357","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T08:20:27Z","timestamp":1662366027000},"page":"383-394","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Targeting <scp>SDF<\/scp>\u20101 as an efficient strategy to resolve skin hyperpigmentation issues with <i>Himanthalia elongata<\/i> extract"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2925-9094","authenticated-orcid":false,"given":"Marie","family":"Meunier","sequence":"first","affiliation":[{"name":"Research &amp; 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