{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:47:02Z","timestamp":1774486022179,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T00:00:00Z","timestamp":1664150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010558","name":"Beiersdorf","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010558","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004192","name":"National Science and Technology Development Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004192","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A better understanding of skin lipidomics and its alteration under treatment administration might offer therapeutic solutions for seborrhea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To quantitatively and qualitatively explore the lipid\u2010modifying effect of the moisturizer containing licochalcone A, 1,2\u2010decanediol, L\u2010carnitine, and salicylic acid (LDCS) in seborrhea participants with and without acne vulgaris (AV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>We conducted an open\u2010label explorative study on 20 seborrhea participants (10 AV and 10 non\u2010AV). All participants applied LDCS for 8\u2009weeks with the addition of benzoyl peroxide 2.5% gel and adapalene 0.1%\/benzoyl peroxide 2.5% gel in AV. Skin surface lipid (SSL) assessments were performed biweekly, using Sebumeter\u00ae and lipid\u2010absorbent Sebutapes\u00ae to collect forehead SSL for profile analysis by gas chromatography\u2013mass spectrometry (GC\u2013MS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SSL amount significantly decreased since week 2 in AV (<jats:italic>p<\/jats:italic>\u2010value\u00a0=\u00a00.0124) and week 6 in non\u2010AV (<jats:italic>p<\/jats:italic>\u2010value\u00a0=\u00a00.0098), respectively. Twenty\u2010two important SSLs were annotated from GC\u2013MS analysis, comprising 19 free fatty acids, cholesterol, squalene, and glycerol. There was a significant reduction in 5 and 13 lipid components in AV and non\u2010AV groups, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LDCS, either alone or with topical acne treatment, demonstrated substantial sebusuppressive and lipid\u2010modifying effects among seborrhea participants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15381","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T12:06:00Z","timestamp":1663157160000},"page":"7081-7089","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Influence of moisturizer containing licochalcone A, 1,2\u2010decanediol, L\u2010carnitine, and salicylic acid on facial skin lipidome among seborrhea participants"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4017-5473","authenticated-orcid":false,"given":"Chanidapa","family":"Wongtada","sequence":"first","affiliation":[{"name":"Division of Dermatology, Department of Medicine, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Putthamas","family":"Pewlong","sequence":"additional","affiliation":[{"name":"Molecular Crop Research Unit, Department of Biochemistry, Faculty of Science Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pravit","family":"Asawanonda","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nopadon","family":"Noppakun","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pornkanok","family":"Pongpamorn","sequence":"additional","affiliation":[{"name":"National Omics Center National Science and Technology Development Agency  Pathum Thani Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atchara","family":"Paemanee","sequence":"additional","affiliation":[{"name":"National Omics Center National Science and Technology Development Agency  Pathum Thani Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Supaart","family":"Sirikantaramas","sequence":"additional","affiliation":[{"name":"Molecular Crop Research Unit, Department of Biochemistry, Faculty of Science Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8975-0523","authenticated-orcid":false,"given":"Chanat","family":"Kumtornrut","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000029945"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-6-80"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000338978"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.D008094"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.1.2.7811"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/321494"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12280318"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5954034"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.98006"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2857812"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2015.1079298"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12168"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.4236\/jcdsa.2014.42012"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13274"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03685.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-29742-7"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1986.tb04061.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/530429"},{"issue":"2","key":"e_1_2_10_20_1","first-page":"18","article-title":"Acne vulgaris and the epidermal barrier: Is acne vulgaris associated with inherent epidermal abnormalities that cause impairment of barrier functions? 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