{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T15:18:15Z","timestamp":1780586295408,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:00:00Z","timestamp":1664496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Rosacea is a chronic inflammatory skin disease affecting the face, and the current treatment effect is not satisfactory. Based on the photomodulation of optimal pulse technology (OPT), we developed a novel treatment mode, namely, advanced OPT with low energy, three pulses, and long pulse width (AOPT\u2010LTL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We aimed to explore the feasibility and underlying molecular mechanisms of AOPT\u2010LTL treatment in a rosacea\u2010like mouse model. Furthermore, we evaluated the safety and efficacy in patients with erythematotelangiectatic rosacea (ETR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Morphological, histological, and immunohistochemical analyses were used to investigate the efficacy and mechanisms of AOPT\u2010LTL treatment in the LL\u201037\u2010induced rosacea\u2010like mouse model. Moreover, 23 patients with ETR were included and received different times of treatment at intervals of 2\u2009weeks depending on the severity of their condition. The treatment effect was assessed by comparing clinical photographs at baseline, 1\u2009week, and 3\u2009months after treatment, combined with the red value, GFSS, and CEA scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After the AOPT\u2010LTL treatment of the mice, we observed that the rosacea\u2010like phenotype, inflammatory cell infiltration, and vascular abnormalities were significantly ameliorated, and the expression of the core molecules of rosacea was significantly inhibited. In the clinical study, the AOPT\u2010LTL treatment exerted satisfactory therapeutic effects on erythema and flushing of ETR patients. No serious adverse events were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>AOPT\u2010LTL is a safe and effective method for the treatment of ETR.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15384","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T18:33:06Z","timestamp":1663093986000},"page":"6767-6775","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Novel technique for rosacea treatment using optimal pulse technology: In vivo and clinical studies"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2128-4618","authenticated-orcid":false,"given":"Jiachen","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Medical Cosmetology Yanbian University Hospital  Yanji China"},{"name":"Department of Dermatology Yanbian University Hospital  Yanji 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