{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:11:15Z","timestamp":1785305475123,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T00:00:00Z","timestamp":1664755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003970","name":"Isfahan University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Solar lentigo (SL) is a benign hyperpigmented spot occurring due to ultraviolet exposure, most commonly in the elderly. We aimed to compare the safety and efficacy of trichloroacetic acid (TCA) peeling with Q\u2010switched laser in the treatment of SLs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This assessor\u2010blind split\u2010hand randomized controlled trial included 45 patients with symmetric SLs on the back of their hands referred to the dermatology clinics from March 1 to June 24, 2021. TCA 35% was applied to the back of one hand, and the contralateral hand received Q\u2010switched laser. The interventions were repeated for a total of three sessions 4\u2009weeks apart. Eight weeks after the last treatment session, lesion lightening was graded from 1 to 4. Patient satisfaction with treatment was assessed using a visual analogue scale (VAS). Adverse events were also noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 45 patients included in the current study with a mean age of 52.71\u2009\u00b1\u20099.73\u2009years, 11 (24.4%) were male. The Fitzpatrick skin type was II in 11 patients (24.4%), III in 23 (51.1%), and IV in 11 (24.4%). Lesion lightening and patient satisfaction were both significantly better with Q\u2010switched laser compared to TCA peeling (standardized mean difference [SMD]\u00a0=\u00a0\u22121.25, 95% confidence interval [CI] \u20101.69; \u22120.79, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 and SMD\u00a0=\u00a0\u20101.12, 95% CI \u20101.56; \u22120.67, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, respectively). Overall, post\u2010inflammatory hyperpigmentation (PIH) occurred in one patient in the laser group and for in the TCA group. Also, erythema and pruritus were observed in all patients of both groups after intervention which were treated with topical repair cream.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Q\u2010switched laser was superior to TCA peeling for the treatment of SLs in terms of lesion lightening and patient satisfaction with a large effect.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15385","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T11:48:44Z","timestamp":1663156124000},"page":"6776-6782","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Q\u2010switched frequency\u2010doubled Nd:<scp>YAG<\/scp> (532\u2009nm) laser versus trichloroacetic acid 35% peeling in the treatment of dorsal hand solar lentigo: An assessor\u2010blind split\u2010hand randomized controlled trial"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0206-0352","authenticated-orcid":false,"given":"Fariba","family":"Iraji","sequence":"first","affiliation":[{"name":"Department of Dermatology, Skin Diseases and Leishmaniasis Research Center Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6073-1775","authenticated-orcid":false,"given":"Azam","family":"Mousavi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Skin Diseases and Leishmaniasis Research Center Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8428-6186","authenticated-orcid":false,"given":"Nazila","family":"Poostiyan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Skin Diseases and Leishmaniasis Research Center Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5058-9050","authenticated-orcid":false,"given":"Mina","family":"Saber","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Skin Diseases and Leishmaniasis Research Center Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-20270-4_16"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13458"},{"key":"e_1_2_11_4_1","volume-title":"The Pigmentary System: Physiology and Pathophysiology","author":"Nordlund 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freckles","volume":"13","author":"Tehranchinia Z","year":"2010","journal-title":"Iran J Dermatol"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.1999.08171.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.7.841"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22472"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20244"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.12.043"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/147641702321136246"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2012.01574.x"},{"issue":"4","key":"e_1_2_11_21_1","first-page":"239","article-title":"Changes of epidermal Langerhans cells in skin treated with trichloroacetic acid","volume":"15","author":"Sakai A","year":"2005","journal-title":"Eur J 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