{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:22:04Z","timestamp":1783570924414,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T00:00:00Z","timestamp":1664064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To explore the short\u2010 and long\u2010term effects of UVB phototherapy preceding a fractional CO<jats:sub>2<\/jats:sub> laser\u2010UVB protocol in patients with resistant nonsegmental vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This single\u2010center, prospective, split\u2010face\/body, evaluator\u2010blinded study included adult patients with stable vitiligo refractory to conventional treatments. Two symmetrical lesions were selected. Phototherapy was delivered with one side covered, until minimal erythema. Within 3\u2009days, 31\u2010month\u2010apart sessions of laser were performed on both sides. After each laser session, phototherapy was resumed three times weekly, with all lesions uncovered, until 8\u2009weeks after the last laser session. At baseline, at the end of treatment, and 5\u2009years later, a Mean Improvement Score by Physician (MISP) and a patient satisfaction 10\u2010point visual analog score (VAS) were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten patients (8 women and 2 men) were included; their mean age was 32.9\u2009years; phototype III was predominant; the mean duration of vitiligo was 3\u2009years. At the end of treatment and 5\u2009years later, scores of lesions treated with UVB\u2010CO<jats:sub>2<\/jats:sub>\u2010UVB (mean MISP 3.0 and 2.9, mean \u0394VAS 4.5 and 3.9, respectively), were higher than those of lesions treated only with CO<jats:sub>2<\/jats:sub>\u2010UVB (mean MISP 2.5 and 2.4, mean \u0394VAS 4.1 and 3.6, respectively). After 5\u2009years, one patient lost his partial response and two patients developed light hyperpigmentation on both sides.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Exposure to UVB before CO<jats:sub>2<\/jats:sub>\u2010UVB explains the higher scores as it was the only variable between the two sides. It may improve the response of resistant lesions with a constantly sustained result over 5\u2009years.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15396","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T13:44:49Z","timestamp":1663595089000},"page":"6783-6787","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Beneficial <scp>UVB<\/scp> phototherapy preceding a fractional <scp>CO<sub>2<\/sub> laser\u2010UVB<\/scp> protocol in refractory non\u2010segmental vitiligo"],"prefix":"10.1111","volume":"21","author":[{"given":"Josiane","family":"Helou","sequence":"first","affiliation":[{"name":"School of Medicine Universit\u00e9 Saint\u2010Joseph  Beirut Lebanon"},{"name":"Dermatology Department H\u00f4tel\u2010Dieu de France Hospital  Beirut 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