{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:11:46Z","timestamp":1787015506649,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T00:00:00Z","timestamp":1664064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>One of the most prevalent skin disorders is acne vulgaris. It is a distressing problem among young adults and adolescents. The pathophysiology of AV is significantly influenced by certain immune response cells. Acne's localized tissue inflammatory reactions are brought on by the bacteria Cutibacterium acnes, which also causes the release of several inflammatory mediators.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim of the Work<\/jats:title>\n                    <jats:p>To measure the serum levels of IL\u20101 and IL\u201012, two pro\u2010inflammatory cytokines, and IL\u201010, an anti\u2010inflammatory cytokine, in AV patients and link those levels with the severity of the condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This study included 19 males and 23 females with AV(\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a042), with mean age of 21.79\u2009\u00b1\u20093.5. The control group included 19 males and 23 female (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a042) with mean age of 22.05\u2009\u00b1\u20093.3 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.729). Serum levels of IL\u20101\u03b2 was significantly higher in patients with AV as than controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Similarly, the serum levels of IL\u201012 were significantly higher in AV cases than controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). On the contrary, the median IL\u201010 was significantly lower in AV cases than controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.015). The correlation between serum levels of IL\u20101\u03b2 and IL\u201012 in AV patients and disease severity was insignificant (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u22120.04,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.404) and (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u22120.19,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.118, respectively). (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u22120.19,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.118) On the contrary, there was a significant negative correlation between serum levels of IL\u201010 in AV patients and disease severity (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u22120.43,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results indicate significant alterations in the monocyte\u2010derived cytokine (MDCs) profile in patients with AV, IL\u20101 and IL\u201012 serum levels rose while IL\u201010 levels fell, reflecting an increase in pro\u2010inflammatory cytokines and a decrease in anti\u2010inflammatory cytokines. These highlight the important role played by monocytes in the pathogenesis of AV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.15399","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T10:13:36Z","timestamp":1663668816000},"page":"7100-7106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Evaluation of serum levels of interleukins 1\u2010beta, 10 and 12 in patients with acne vulgaris"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5873-3907","authenticated-orcid":false,"given":"Marwa","family":"Mohamed","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology, Faculty of Medicine Sohag University  Sohag Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan Abdel Aaty","family":"Shehata","sequence":"additional","affiliation":[{"name":"Department of Dermatology, 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