{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T17:24:01Z","timestamp":1778520241089,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T00:00:00Z","timestamp":1665705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Given that most patients with moderate to severe acne develop post\u2010acne scars, many treatment modalities can be used to ameliorate scaring; chemical peels, surgical excision, dermabrasion, fat transfer, autologous collagen, punch grafting, diverse filler injection, and lasers. Microneedling is one of the promising modalities based on the breaking of dermis\u2010damaged collagen and enhancing new collagen formation.<\/jats:p><jats:p>Microbotox (Mesobotox) injection may have a beneficial effect by causing muscular paralysis with subsequent dermal edema due to transient and mild lymphatic insufficiency. The comparison between these two modalities has not been yet assessed.<\/jats:p><jats:p>The aim of this study was to evaluate and compare the safety and efficacy of both methods (Microbotox and microneedling) in the treatment of atrophic post\u2010acne scars.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between May 2021 to April 2022, patients with atrophic post\u2010acne scars were selected from the out\u2010patients clinics of the Department of Dermatology, Faculty of Medicine. The face was divided into two sides: the right side was treated with Mesobotox for three sessions once monthly and followed up 3 months later after the last session and the left side was treated with dermapen (microneedling) for six sessions every 2\u2009weeks and followed up 3 months after the last session. The feasibility, safety, and efficacy of both lines of treatment were studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This study included 20 patients with atrophic post\u2010acne scars. They were 13 females (65%) and 7 males (35%), and their ages ranged between 15 and 35\u2009years with a mean\u2009\u00b1\u2009sd age of 24.40\u2009\u00b1\u20095.90 based on the significant improvement between S1 (baseline acne scar score) and both S2 (acne scar score at end of treatment) and S3 (acne scar score 3\u00a0months after the last session). Microneedling showed also similar results to Mesobotox.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Microbotox and microneedling were effective and tolerated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15419","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T14:13:39Z","timestamp":1664374419000},"page":"6734-6741","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Microbotox (Mesobotox) versus microneedling as a new therapeutic modality in the treatment of atrophic post\u2010acne scars"],"prefix":"10.1111","volume":"21","author":[{"given":"Noha E.","family":"Mohamed","sequence":"first","affiliation":[{"name":"Department of Dermatology, STDs and Andrology, Faculty of Medicine Fayoum University  Fayoum Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samar N.","family":"Shabaan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, STDs and Andrology, Faculty of Medicine Fayoum University  Fayoum Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amel H.","family":"Raouf","sequence":"additional","affiliation":[{"name":"Department of Dermatology, STDs and Andrology, Faculty of Medicine Fayoum University  Fayoum Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12149"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13675"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.167272"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000746"},{"key":"e_1_2_11_6_1","first-page":"50","article-title":"Practical evaluation and management of atrophic acne scars: tips for the general dermatologist","volume":"4","author":"Fife D","year":"2011","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_11_7_1","first-page":"50","article-title":"Atrophic acne scarring: a review of treatment options","volume":"8","author":"Hession MT","year":"2015","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.05.029"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200001010-00001"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14751"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijwd.2015.03.004"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2009.03291.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102410364676"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000001827"},{"issue":"9","key":"e_1_2_11_15_1","first-page":"847","article-title":"Use of intradermal botulinum toxin to reduce sebum production and facial pore size","volume":"7","author":"Shah AR","year":"2008","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000153236.79775.A0"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2006.32354.x"},{"issue":"1","key":"e_1_2_11_18_1","article-title":"Role of microneedling in atrophic post\u2010acne scars: an experience from a Tertiary care hospital","volume":"13","author":"Tirmizi SS","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.53096"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3889\/oamjms.2019.098"},{"key":"e_1_2_11_21_1","first-page":"36","article-title":"Microneedling therapy for atrophic acne scars: an objective evaluation","volume":"8","author":"El\u2010Domyati M","year":"2015","journal-title":"J Clin Aesthet Dermatol"},{"issue":"4","key":"e_1_2_11_22_1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.5114\/ada.2021.108913","article-title":"Double\u2010blind, randomized controlled trial comparing the use of microneedling alone versus chemical peeling alone versus a combination of microneedling and chemical peeling in the treatment of atrophic post\u2010acne scars. An assessment of clinical effectiveness and patients' quality\u2010of\u2010life","volume":"38","author":"Grochowiec M","year":"2021","journal-title":"Postepy Dermatol Alergol"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.788754"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.15419","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.15419","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.15419","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T10:29:13Z","timestamp":1706783353000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.15419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,14]]},"references-count":22,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1111\/jocd.15419"],"URL":"https:\/\/doi.org\/10.1111\/jocd.15419","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,14]]},"assertion":[{"value":"2022-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}