{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:24:54Z","timestamp":1792463094002,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T00:00:00Z","timestamp":1667174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bakuchiol (BAK), a meroterpene phenol abundant in the plant <jats:italic>Psoralea corylifolia<\/jats:italic>, is an emerging cosmeceutical agent with promising anti\u2010aging, anti\u2010inflammatory, and antibacterial properties. The trend for \u201cclean\u201d skincare products and search for anti\u2010aging retinoid alternatives have poised BAK as a \u201cmust\u2010have\u201d ingredient in skincare.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>Our aim was to review the data for the applications of BAK in dermatology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a systematic review of PubMed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty articles matched our search terms [\u201cBakuchiol\u201d and \u201cDermatology\u201d] or [\u201cBakuchiol\u201d and \u201cSkin\u201d] of which one did not meet inclusion criteria, 16 were pre\u2010clinical studies, seven clinical studies, three commentaries, two narrative reviews, and one report on adverse events. BAK has been mostly studied for its effects on photoaging, acne, and post\u2010inflammatory hyperpigmentation (PIH), showing beneficial results comparable to those achieved by topical retinoids. While having no structural resemblance to retinoids, BAK can function as a retinol analog, through retinol\u2010like regulation of gene expression. In in vivo studies, BAK was used alone or in combination with other products resulting in a significant reduction in photodamage, hyperpigmentation, wrinkle scores, and acne severity. Additionally, in vitro studies hinted at its anti\u2010cancer properties by inhibiting epidermal growth factor induced neoplastic cell transformation. Also, demonstrated potential applications in psoriasis by normalizing keratinocyte activity and in pigmentary disorders through inhibition of melanogenesis. There was one adverse event case reported of contact dermatitis in the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Bakuchiol is a retinol alternative with anti\u2010aging, antibacterial, and anti\u2010inflammatory properties. Additional studies are warranted to better understand its applications in dermatology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15420","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T05:50:11Z","timestamp":1664517011000},"page":"6636-6643","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Applications of bakuchiol in dermatology: Systematic review of the literature"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9601-1120","authenticated-orcid":false,"given":"Carolina","family":"Puyana","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Illinois at Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5689-8062","authenticated-orcid":false,"given":"Neha","family":"Chandan","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Illinois at Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Tsoukas","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Illinois at Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.12.009"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16918"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12117"},{"issue":"8","key":"e_1_2_6_5_1","first-page":"39","article-title":"Melatonin, bakuchiol and ascorbyl tetraisopalmitate synergize to modulate gene expression and restore hypoxia\u2010inducible factor 1 signaling in UV\u2010exposed skin","volume":"65","author":"Narda M","year":"2018","journal-title":"Cell Mol 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