{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:50:24Z","timestamp":1777942224963,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne vulgaris is one of the most common dermatological diseases. Some topical treatments for acne used in combination, such as blue light and topical antibiotics (such as metronidazole) by needle\u2010free jet injection (NFJI), are becoming prevalent in clinical practice, but the efficacy remains uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In order to investigate the effect of blue light combined with metronidazole by NFJI in the treatment of acne, the 251 enrolled patients were randomly assigned into the blue light group, metronidazole (MNZ) group, and MNZ\u2009+\u2009blue light group, and then received 6\u2010weeks' treatment. A variety of objective and subjective methods such as clinical pictures, skin barrier physiological parameters (including trans\u2010epidermal water loss (TEWL), stratum corneum hydration, facail surface sebum, erythema and pigmentation), the Investigator Global Assessment score, acne lesion count assessment, Patients' Self\u2010Assessment, and VAS score were used to evaluate the efficacy and side effects of the treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to the baseline, the MNZ\u2009+\u2009blue light group showed significant improvement in acne lesion count reduction, TEWL, straum corneum hydration, facial surface sebum and erythema (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.05). The MNZ\u2009+\u2009blue light group showed significant differences compared with the MNZ group and blue light group in terms of acne lesion count reduction and erythema (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.05) Compared to the MNZ group, the MNZ\u2009+\u2009blue light group demonstrated significant improvement in TEWL and sebum (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.05). While compared to the blue light group, the MNZ\u2009+\u2009blue light group showed significant improvement in hydration (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.05). There was no statistically significant difference among the three groups in pigmentation (<jats:italic>p<\/jats:italic>\u00a0&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The combination of MNZ by NFJI and blue light has a synergistic effect and can relieve acne skin lesion within 6\u2009weeks in the treatment of moderate and moderate\u2013to\u2013severe facial acne vulgaris, meanwhile, this method has a good safety.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15442","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T08:15:19Z","timestamp":1665216919000},"page":"569-576","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Therapeutic efficacy of metronidazole by needle\u2010free jet injection combined with blue light therapy in <scp>Moderate\u2010to\u2010Severe<\/scp> facial acne vulgaris"],"prefix":"10.1111","volume":"22","author":[{"given":"Lu","family":"Yi","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology\/Cosmetic Dermatology Affiliated Hospital of Guilin Medical University  Guilin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Gao","sequence":"additional","affiliation":[{"name":"Departments of Dermatology, The Third Xiangya Hospital Central South University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lv","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid surgery Affiliated Hospital of Guilin Medical University  Guilin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Departments of Stomatology, The Third Xiangya Hospital Central South University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangru","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid surgery Affiliated Hospital of Guilin Medical University  Guilin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengyuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology\/Cosmetic Dermatology Affiliated Hospital of Guilin Medical University  Guilin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjie","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology\/Cosmetic Dermatology Affiliated Hospital of Guilin Medical University  Guilin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid surgery Affiliated Hospital of Guilin Medical University  Guilin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nianzhen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid surgery Affiliated Hospital of Guilin Medical University  Guilin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanqing","family":"Lao","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology\/Cosmetic Dermatology Affiliated Hospital of Guilin Medical University  Guilin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianyun","family":"Lu","sequence":"additional","affiliation":[{"name":"Departments of Dermatology, The Third Xiangya Hospital Central South University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology\/Cosmetic Dermatology Affiliated Hospital of Guilin Medical University  Guilin China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,14]]},"reference":[{"issue":"8","key":"e_1_2_9_2_1","first-page":"734","article-title":"Diagnosis and treatment of acne","volume":"86","author":"Titus SHJ","year":"2012","journal-title":"Am Fam Physician"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13499"},{"key":"e_1_2_9_4_1","unstructured":"Androgen metabolism in sebaceous glands from subjects with and without acne\u2010sebum."},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/s21206943"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9030237"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007917.pub2"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1370\/afm.2445"},{"key":"e_1_2_9_9_1","unstructured":"Pathogens and Disease 2006;Ashkenazi \u2013 Eradication ofPropionibacterium acnesby its endogenic porphyrins after."},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2012.11.022"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2012.02905.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2009.01.003"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-019-02383-1"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.16761\/j.cnki.1000-4963.2019.09.020"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2012.07.001"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2016.10.012"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-021-00624-5"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/19381980.2017.1348444"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2019.08.023"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B1100285"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21081063"},{"issue":"4","key":"e_1_2_9_22_1","first-page":"173","article-title":"A double blind study of the effectiveness of sertaconazole 2% cream vs. metronidazole 1% gel in the treatment of seborrheic dermatitis","volume":"59","author":"Goldust M","year":"2013","journal-title":"Ann Parasitol"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/ico.0000000000002911"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.555824"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12186"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.15442","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.15442","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.15442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T06:06:49Z","timestamp":1717654009000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.15442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,14]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1111\/jocd.15442"],"URL":"https:\/\/doi.org\/10.1111\/jocd.15442","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,14]]},"assertion":[{"value":"2022-07-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}