{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T05:32:07Z","timestamp":1771047127924,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T00:00:00Z","timestamp":1667174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004491","name":"Balikesir \u00dcniversitesi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004491","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Metabolic syndrome and insulin resistance may accompany rosacea. Zinc\u2010alpha\u20102 glycoprotein (ZAG) is an adipokine involved in lipid, glucose, and insulin metabolism and might be associated with metabolic syndrome and insulin resistance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate the serum ZAG levels, presence of metabolic syndrome, insulin resistance, and the correlation between ZAG levels, rosacea severity, and metabolic syndrome in patients with rosacea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>Seventy\u2010nine patients with rosacea and 80 healthy volunteers were included. Anthropometric and demographic features, personal and family histories, clinical data, the subtype, severity, and duration of rosacea were recorded. Metabolic syndrome, insulin resistance, and dyslipidemia were evaluated in both groups. Fasting blood sugar, lipid panel, C\u2010reactive protein, sedimentation rate, insulin, and serum ZAG levels were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Frequency of metabolic syndrome, systolic and diastolic blood pressures, and C\u2010reactive protein levels were significantly higher in the rosacea group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 and <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001, respectively). Frequency of dyslipidemia and insulin resistance did not significantly differ between the groups (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.175 and 0.694, respectively). The mean serum ZAG levels were lower in the rosacea group, but no significant difference was evident. In rosacea patients with metabolic syndrome, serum ZAG levels were significantly lower (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.043); however, serum ZAG levels, insulin, and the homeostasis model assessment\u2010estimated insulin resistance values were significantly higher (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.168, 0.013 and 0.001, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Metabolic syndrome, high blood pressure, and high C\u2010reactive protein levels were associated with rosacea indicating chronic systemic inflammation. ZAG levels were associated with metabolic syndrome in patients with rosacea but not associated with rosacea subtype and disease severity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15447","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T06:38:46Z","timestamp":1665211126000},"page":"645-650","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Serum zinc\u2010alpha\u20102 glycoprotein and insulin levels and their correlation with metabolic syndrome in patients with rosacea"],"prefix":"10.1111","volume":"22","author":[{"given":"Rana Basara","family":"Sahin","sequence":"first","affiliation":[{"name":"Department of Dermatology Menemen State Hospital  \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma Arzu","family":"Kilic","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Balikesir University  Balikesir 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