{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T03:33:17Z","timestamp":1764646397154,"version":"3.40.5"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T00:00:00Z","timestamp":1667174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Alopecia areata (AA) is an autoimmune and inflammatory disease characterized by localized or diffuse non\u2010scarring hair loss. The serum C\u2010reactive protein (CRP)\/albumin ratio (CAR) is a novel inflammatory marker and a significant prognostic indicator in several diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>We aimed to explore CAR in AA patients and healthy controls and analyze the possible correlation between CAR and disease severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The present study was conducted with 65 eligible AA patients and 65 age\u2010 and gender\u2010matched healthy controls. Disease severity was analyzed based on the Severity of Alopecia Tool (SALT) score. The CAR score was calculated by dividing serum CRP by the albumin content in both patient and healthy control groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>56.9% of the patients were male and 43.1% were female, and the mean age was 31.93\u2009\u00b1\u20099.67. The patient group'\u00a0mean CAR level (0.42\u2009\u00b1\u20090.3) was statistically higher than that of the healthy controls (0.07\u2009\u00b1\u20090.04), (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). There were positive correlations between disease severity, CAR (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.65; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), and CRP (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.66; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), while the correlation between disease severity and albumin was negative (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.56; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). In the receiver operating characteristic analysis conducted on disease severity, the area under the curve was 0.16 for albumin, 0.92 for CRP, and 0.95 for CAR. The optimum CAR for AA severity was 0.38 with 87% sensitivity and 92% specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the study, we determined that the CAR was higher in AA patients when compared to the control group, and the elevation was associated with disease severity. The present study findings demonstrated that alopecia areata was associated with systemic inflammation, and CAR is a useful inflammatory marker in AA patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15460","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T05:05:05Z","timestamp":1665637505000},"page":"7194-7199","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of the serum C\u2010reactive protein\u2013albumin ratio and\u00a0its relationship with disease severity IN alopecia areata: A\u00a0prospective case\u2013control study"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5838-8528","authenticated-orcid":false,"given":"B\u00fclent Nuri","family":"Kalayc\u0131","sequence":"first","affiliation":[{"name":"Department of Dermatology Malatya Turgut Ozal University Faculty of Medicine  Malatya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0909-589X","authenticated-orcid":false,"given":"\u0130lknur","family":"Balta","sequence":"additional","affiliation":[{"name":"Department of Dermatology Malatya Training And Research Hospital  Malatya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.11"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.464"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.04.1141"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016\u2010021\u201008883\u20100"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12808"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4948-7"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-017-4400-1"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.897460"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6621101"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14504"},{"key":"e_1_2_11_12_1","first-page":"522","article-title":"Oxidative stress\u2010 related markers and alopecia areata through latex turbidimetric immunoassay method","volume":"53","author":"Georgescu SR","year":"2016","journal-title":"Mater Plast"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.26722"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12396"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10123397"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-6612-4_15"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2018.02.013"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI18921"},{"issue":"2","key":"e_1_2_11_19_1","first-page":"341","article-title":"New evidences for C\u2010reactive protein (CRP) deposits in the arterial intima as a cardiovascular risk factor","volume":"3","author":"Montecucco F","year":"2008","journal-title":"Clin Interv Aging"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12257"},{"key":"e_1_2_11_21_1","unstructured":"VekariaAS BrunnerPM AleisaAI et al.Show increases in serum C\u2010reactive protein levels correlating with skin disease activity [version 2; 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