{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:47:59Z","timestamp":1761864479200,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:00:00Z","timestamp":1667865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The risk of gout amid patients with acne keloidalis nuchae (AKN) has not been investigated in the past.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the risk of developing gout among patients with AKN relative to control subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A population\u2010based retrospective study followed patients with AKN (<jats:italic>n<\/jats:italic>\u00a0=\u00a02677) and age\u2010, sex\u2010, and ethnicity\u2010matched control subjects (<jats:italic>n<\/jats:italic>\u00a0=\u00a013\u2009190). The incidence of new\u2010onset gout was compared between the two groups. Hazard ratio (HR) for the risk of gout was obtained using a multivariate Cox regression model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence rate of gout was 1.12 (95% CI, 0.68\u20131.76) and 0.48 (95% CI, 0.34\u20130.66) per 1000 person\u2010years among patients with AKN and controls, respectively. The crude risk of developing gout was significantly higher in patients with AKN (HR, 2.27; 95% CI, 1.26\u20134.10;<jats:italic>p<\/jats:italic>\u00a0=\u00a00.007). After controlling for age, sex, and ethnicity, AKN emerged as an independent risk factor of gout (adjusted HR, 2.34; 95% CI, 1.29\u20134.22;<jats:italic>p<\/jats:italic>\u00a0=\u00a00.005). When adjusting for other confounders such as body mass index, diabetes mellitus, hypertension, and dyslipidemia, the risk of gout in AKN fell out of significance (adjusted HR, 1.39; 95% CI, 0.73\u20132.65;<jats:italic>p<\/jats:italic>\u00a0=\u00a00.311),<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with AKN experience an increased risk of gout. The risk is not independent and is mainly mediated through the metabolic comorbidities typifying AKN. We recommend screening for gout in patients with suggestive complaints.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15476","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T10:00:12Z","timestamp":1667901612000},"page":"284-288","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The burden of gout in acne keloidalis nuchae\u2014Insights from a population\u2010based study"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2397-6316","authenticated-orcid":false,"given":"Eran","family":"Shavit","sequence":"first","affiliation":[{"name":"Dermatology Clinic Wolfson Medical Center Holon Israel"},{"name":"The Sackler Faculty of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnon","family":"Cohen","sequence":"additional","affiliation":[{"name":"Clalit Health Services Tel\u2010Aviv Israel"},{"name":"Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences Ben\u2010Gurion University of the Negev Beer Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilach","family":"Zoller","sequence":"additional","affiliation":[{"name":"Clalit Health Services Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erez","family":"Onn","sequence":"additional","affiliation":[{"name":"Barch Padeh Medical Center Poriya Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalaf","family":"Kridin","sequence":"additional","affiliation":[{"name":"Barch Padeh Medical Center Poriya Israel"},{"name":"L\u00fcbeck Institute of Experimental Dermatology University of L\u00fcbeck L\u00fcbeck Germany"},{"name":"Azrieli Faculty of Medicine Bar\u2010Ilan University Safed 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