{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T22:12:28Z","timestamp":1769119948929,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T00:00:00Z","timestamp":1667779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Purpose<\/jats:title><jats:p>Vitiligo is one of the most challenging dermatological diseases with little improvement promises. Various modalities of treatment both medical and surgical have been used in the treatment of vitiligo. Some proved to be effective, others with controversial results and the rest were effective less. The aim of the present study was to evaluate the additional effect of topical 5\u2010fluorouracil after micro\u2010needling to excimer light (308\u2009nm) in treatment of non\u2010segmental vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty patients were included in the present study, only 33 patients continued the treatment for 6\u00a0months. Two patches were selected in every patient to be treated, one patch with micro\u2010needling then application of 5 FU and excimer (Group A), and the other with excimer only (Group B).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The treatment with the combination of micro\u2010needling then application of 5 FU and excimer showed significant earlier response versus excimer alone. Also, the percentage of re\u2010pigmentation was higher in the patches treated with the combination especially in the face and trunk. The combination of 5 FU after micro\u2010needling and Excimer is more suitable for localized and focal vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Topical 5 FU after micro\u2010needling is a promising, rapid, and cost\u2010effective therapeutic strategy for treatment of non\u2010segmental vitiligo It had limited side effects, and the best response was reported for lesions affecting face and trunk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15481","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T19:16:35Z","timestamp":1667848595000},"page":"810-821","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy and safety of micro\u2010needling combined with topical 5\u2010fluorouracil and excimer light vs. excimer light alone in treatment of non\u2010segmental vitiligo: A comparative study"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8016-116X","authenticated-orcid":false,"given":"Mohammad A.","family":"Saad","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venerology, and Andrology Faculty of Medicine Al\u2010Azhar University (Assiut)  Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaled Mohamed","family":"Tawfik","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venerology, and Andrology Faculty of Medicine Al\u2010Azhar University (Assiut)  Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hazem L.","family":"Abdelaleem","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venerology, and Andrology Faculty of Medicine Al\u2010Azhar University (Assiut)  Assiut 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