{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:55:03Z","timestamp":1787500503897,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Rosacea may contribute to the development of cardiovascular (CV) diseases by causing endothelial dysfunction (ED), which is known to be the initial step of atherosclerosis, due to its inflammatory features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to assess ED in rosacea patients using the flow\u2010mediated dilatation (=dilation) (FMD) method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Seventy\u2010three rosacea patients and 73 age, gender\u2010matched healthy volunteers were enrolled. Individuals with cardiac risk factors, pregnant, and lactating women were excluded. Demographic, clinical data and anthropometric measurements were recorded. FMD measurement was performed ultrasonographically by a cardiologist. Systolic and diastolic blood pressures (BP) were measured and hemogram, erythrocyte sedimentation rate (ESR), C\u2010Reactive Protein (CRP), total cholesterol, triglyceride, low\u2010density lipoprotein (LDL), high\u2010density lipoprotein (HDL), neutrophil\/lymphocyte ratio (NLR), platelet\/lymphocyte ratio (PLR), mean platelet volume (MPV), and fasting blood glucose values were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The FMD value was statistically lower in rosacea patients compared with healthy controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.000). Metabolic syndrome, systolic and diastolic BPs, and plasma NLR were higher in the rosacea group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.009,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.000,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.000,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.000, respectively). According to the multivariate linear regression analysis, rosacea type significantly predicted FMD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Rosacea is not only a disease limited to the skin, but it may also have systemic involvement. A significant difference was found between FMD values measured in between the case and control groups, suggesting rosacea may have an atherogenic effect. Possible cardiac risks should be considered in rosacea patients, and further evaluation could be warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.15492","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T12:46:50Z","timestamp":1668430010000},"page":"1001-1010","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Evaluation of subclinical atherosclerosis in rosacea patients by flow\u2010mediated dilatation method"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9364-9236","authenticated-orcid":false,"given":"Nazl\u0131","family":"Caf","sequence":"first","affiliation":[{"name":"Department of Dermatology The University of Health Sciences, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9995-2543","authenticated-orcid":false,"given":"Tu\u011fba","family":"\u00d6zk\u00f6k Akbulut","sequence":"additional","affiliation":[{"name":"Department of Dermatology The University of Health Sciences, Haseki Education and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Mustafa","family":"Can","sequence":"additional","affiliation":[{"name":"Department of Cardiology The University of Health Sciences, Haseki Education and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Sar\u0131","sequence":"additional","affiliation":[{"name":"Department of Cardiology The University of Health Sciences, Haseki Education and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fe Nilhan","family":"Ats\u00fc","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences \u0130stanbul Kent University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zafer","family":"T\u00fcrko\u011flu","sequence":"additional","affiliation":[{"name":"Department of Dermatology The University of Health Sciences, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital  Istanbul 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