{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:30:24Z","timestamp":1790955024388,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>When formulating topical products to treat skin diseases and addressing general skin health and cosmesis, most of the focus has traditionally been placed on how any given ingredient may impact the structure, function, and health of human skin elements. However, recent research is beginning to highlight the importance of the skin microbiome in relation to certain skin conditions and general cosmesis. <jats:italic>Cutibacterium acnes<\/jats:italic> is one of the most prolific skin\u2010specific bacterial species. Research has shown that the species is divided into subspecies, some of which are thought to be beneficial to the skin. This paper aims to determine the efficacy of strainXYCM42, a <jats:italic>C. acnes<\/jats:italic> subspecies <jats:italic>defendens<\/jats:italic> derived strain designed to improve the health and appearance of the skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In vitro studies were performed on human keratinocyte and fibroblast monolayers, human peripheral blood mononuclear cells (PBMC), and skin explants to elucidate the effects of live XYCM42 cells and their ferment on human skin cells and tissues. Subsequently, clinical studies were performed using XYCM42\u2010based topical regimens designed to deliver and support the engraftment of live XYCM42 cells onto subjects' skin. Two studies were performed, a 3\u2010week pilot study (<jats:italic>n<\/jats:italic>\u00a0=\u00a010) and a 8\u2010week pivotal study (<jats:italic>n<\/jats:italic>\u00a0=\u00a0121). In the latter, 32 subjects were enrolled for an in\u2010clinic portion for efficacy evaluation, with clinic visits occurring at Baseline, Week 1, Week 4, and Week 8.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In vitro data suggest that XYCM42 and its ferment filtrate have potential to provide benefits to the skin via antioxidant, anti\u2010inflammatory, and select antimicrobial activities. Clinical observation demonstrated that a XYCM42\u2010containing regimen supports a healthy skin environment, promotes increased skin hydration, decreases erythema, calms the skin, and regulates sebum production.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These studies provide further evidence that specific strains of <jats:italic>C. acnes<\/jats:italic>, such as XYCM42, have a more beneficial function regarding skin health and appearance than was previously thought. Appropriate use of formulations derived from symbiotic strains within the skin microbiome can support the development of novel, beneficial topicals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15510","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T16:53:01Z","timestamp":1668444781000},"page":"1031-1045","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Characterization of a live <i>Cutibacterium acnes<\/i> subspecies <i>defendens<\/i> strain <scp>XYCM42<\/scp> and clinical assessment as a topical regimen for general skin health and cosmesis"],"prefix":"10.1111","volume":"22","author":[{"given":"Mun Su","family":"Rhee","sequence":"first","affiliation":[{"name":"Department of Biological Sciences Crown Laboratories  Johnson City Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona 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