{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T16:38:15Z","timestamp":1775839095460,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,27]],"date-time":"2022-11-27T00:00:00Z","timestamp":1669507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vitiligo is a skin disease characterized by a complex etiopathogenesis. Keratinocyte apoptosis may play a role in vitiligo pathogenesis. Aquaporin\u20103 (AQP\u20103) is an aqua\u2010glyceroporin that controls keratinocyte proliferation and differentiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the immunohistochemical expression of AQP\u20103 in lesional and perilesional skin of vitiligo patients compared to healthy control skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 20 patients with generalized non\u2010segmental vitiligo and 20 age\u2010 and sex\u2010matched healthy controls were included. Lesional and perilesional skin of vitiligo patients, as well as normal skin of control subjects, were biopsied. The immunohistochemical expression of AQP3 in the epidermis was examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to control skin, both lesional and perilesional skin showed a significant reduction in the intensity of membranous staining of AQP\u20103 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001, <jats:italic>p<\/jats:italic>\u00a0=\u20090.002, respectively). Moreover, the membrano\u2010cytoplasmic pattern of AQP\u20103 staining was significantly detected in 80% of lesions and 85% of perilesional biopsies, while it was absent in control skin (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001). Additionally, nuclear AQP\u20103 expression was significantly detected in 35% of lesions and 55% of perilesional biopsies, while it was not detected in control skin (<jats:italic>p<\/jats:italic>\u00a0=\u20090.012, <jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001, respectively). No statistically significant difference was detected between lesional and perilesional skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>To our knowledge, this is the first immunohistochemical research to show a significant abnormal nuclear expression of AQP\u20103 in lesional and perilesional skin of vitiligo patients. This abnormality may reflect impaired functions of AQP\u20103, leading to keratinocyte apoptosis with subsequent melanocyte death and development of vitiligo.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15518","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T07:02:36Z","timestamp":1669618956000},"page":"1063-1070","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Abnormal nuclear expression of aquaporin\u20103 in lesional and perilesional skin of vitiligo patients: A novel immunohistochemical finding"],"prefix":"10.1111","volume":"22","author":[{"given":"Hend","family":"Gamil","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology &amp; Andrology, Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magda","family":"Assaf","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad","family":"Khater","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology &amp; Andrology, Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5490-9672","authenticated-orcid":false,"given":"Manal","family":"Fawzy","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology &amp; Andrology, Faculty of Medicine Zagazig University  Zagazig 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