{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:41:24Z","timestamp":1791484884897,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,27]],"date-time":"2022-11-27T00:00:00Z","timestamp":1669507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Oral isotretinoin is the most effective treatment option in patients with acne. However, it can cause various hematologic and biochemical abnormalities. This study aimed to evaluate hematologic abnormalities during oral isotretinoin treatment in patients with acne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>In this cross\u2010sectional study, the hematologic and inflammatory parameters of 138 patients with acne using 0.3\u20101 mg\/kg\/day oral isotretinoin for at least 6\u00a0months were retrospectively analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the study, the female\u2010to\u2010male ratio was 2.83, and the mean age of the patients was 23.1\u2009\u00b1\u20095.8\u2009years. At the third and sixth months of isotretinoin treatment, there was a statistically significant decrease in the neutrophil count compared to the pre\u2010treatment values (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.003 and<jats:italic>p<\/jats:italic>\u00a0=\u00a00.032, respectively). The platelet count showed the most statistically significant increase (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) at the first month of treatment. The most statistically significant decrease in the neutrophil\u2010to\u2010lymphocyte ratio (NLR) was observed at the third month of treatment (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). No significant changes were observed in hemoglobin, hematocrit, white blood cell count, mean corpuscular volume, and mean platelet volume.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There was a decrease in neutrophils and NLR and an increase in platelets during isotretinoin treatment, and these changes were usually mild. However, it would be appropriate to monitor blood counts during treatment in patients with neutropenia or thrombocytosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15532","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T07:34:33Z","timestamp":1669620873000},"page":"1077-1082","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of hematological parameters in patients using systemic isotretinoin with diagnosis of acne vulgaris"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7449-7951","authenticated-orcid":false,"given":"Elif","family":"Demirci Saadet","sequence":"first","affiliation":[{"name":"Department of Dermatology Atilim University, School of Medicine, Medicana International Ankara Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ugur","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Hematology Atilim University, Vocational School of Health Services, Medicana International Ankara Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16430"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.06.025"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.03.019"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.3091"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2019.1591578"},{"issue":"6","key":"e_1_2_8_7_1","first-page":"557","article-title":"Isotretinoin monitoring trends: a national survey of dermatologists","volume":"16","author":"Hobson JG","year":"2017","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1987.01660270025004"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1D098"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(87)80276-1"},{"issue":"2","key":"e_1_2_8_11_1","first-page":"89","article-title":"Effects of isotretinoin on the inflammatory markers and the platelet counts in patients with acne vulgaris","volume":"35","author":"Seckin HY","year":"2016","journal-title":"Cutan Ocul Toxicol"},{"key":"e_1_2_8_12_1","unstructured":"Cancer Therapy Evaluation Program Common Terminology Criteria for Adverse Events Version 3.0 DCTD NCI NIH DHHS March 31 2003 August 9 2006. 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