{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T14:24:31Z","timestamp":1761402271435},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,27]],"date-time":"2022-11-27T00:00:00Z","timestamp":1669507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Scarring is a common and undesirable outcome of acne vulgaris. There are limited effective topical formulations for acne scar treatment. The investigational product, acne scar serum (HEXILAK\u00ae Acne Scar Serum) is latest topical formulation developed for treatment of acne scar with unique ingredients, Kollaren and Exo\u2010T.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Evaluate safety and efficacy of latest acne scar serum on the reduction of acne scars in Indian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Subjects, diagnosed clinically with acne scars with or without hyperpigmentation, of either gender in the age group of 15 to 45\u2009years were enrolled in the study. The investigational acne scar serum was applied twice daily for 3\u00a0months with monthly follow for outcome evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 72 subjects enrolled, 67 completed the study. Most of the subjects, 79.1% showed improvement in acne scar at Day 90. Significant reduction of mean total post\u2010acne hyperpigmentation index (PAHI) was seen at all follow up visits compared with baseline. Significant improvement in mean acne scar depth, mean acne scar volume, and mean L value using 3D imaging were observed at all visits compared with baseline. All side effects reported were mild and overall, it was well tolerated by all subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We found that there was a significant reduction in acne scar and post\u2010acne pigmentation with new acne scar serum as a monotherapy, this needs further confirmation in larger randomized controlled studies. Therefore, topical acne scar serum with unique ingredients Kollaren and Exo\u2010T can be a safe, effective, and new option in the armamentarium of acne scar management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15536","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T07:54:13Z","timestamp":1669622053000},"page":"880-889","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy and safety of innovative acne scar serum in Indian patients (ESTEEM India study)"],"prefix":"10.1111","volume":"22","author":[{"given":"Sanjiv","family":"Kandhari","sequence":"first","affiliation":[{"name":"Dr. Kandhari's Skin Clinic  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil","family":"Ganjoo","sequence":"additional","affiliation":[{"name":"Skinnovation Clinics  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhay","family":"Talathi","sequence":"additional","affiliation":[{"name":"SkinSpace Clinic  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjeev","family":"Aurangabadkar","sequence":"additional","affiliation":[{"name":"Dr. Aurangabadkar's Skin &amp; Laser Clinic  Hyderabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satish","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Indian Cancer Society  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Apratim","family":"Goel","sequence":"additional","affiliation":[{"name":"Cutis Skin Studio  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chetan Y.","family":"Patil","sequence":"additional","affiliation":[{"name":"A. Menarini India Pvt Ltd  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,27]]},"reference":[{"issue":"5","key":"e_1_2_12_2_1","first-page":"276","article-title":"Acne scarring: a review of cosmetic therapies","volume":"95","author":"Lanoue J","year":"2015","journal-title":"Cutis"},{"key":"e_1_2_12_3_1","unstructured":"What causes a pimple to scar? \u2010 Acne.org. 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