{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:14:26Z","timestamp":1787015666024,"version":"build-2736575974"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T00:00:00Z","timestamp":1669939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009754","name":"Galderma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009754","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Transient swelling is common after lip injections with hyaluronic acid (HA) based fillers. Swelling and other injection\u2010site reactions may relate to the injection procedure itself, or to gel properties, which differ between fillers due to differences in manufacturing methods.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n To evaluate safety and effectiveness of lip injections with two HA fillers manufactured using different gel technologies.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In a study sample of 40 subjects, treatment with two soft tissue filler product (HA\n RK<\/jats:sub>\n or HA\n JUS<\/jats:sub>\n ) was randomly assigned. Subjects were injected with 0.5\u00a0cc per upper and lower lip using a standardized injection procedure. Early\u2010onset adverse events (AEs) were assessed by evaluation up to Day 14. Aesthetic improvement, subject satisfaction, and AEs post\u2010Day 14 were assessed up to 24\u2009weeks.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In subjects treated with HA\n RK<\/jats:sub>\n , the intensity of early onset swelling, erythema, and pain\/tenderness was lower than in subjects treated with HA\n JUS<\/jats:sub>\n . Aesthetic improvement was achieved in both groups, and most subjects were satisfied with the appearance of their lips. Treatment\u2010related AEs post\u2010Day 14 mostly related to the implant site; most were mild\u2010to\u2010moderate, and none were serious.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The intensity of early\u2010onset swelling, and other injection\u2010site reactions was lower in subjects treated with HA\n RK<\/jats:sub>\n than in subjects treated with HA\n JUS<\/jats:sub>\n . Since both the injection volume and injection procedure were standardized, the difference in local tolerability between the two HA fillers may relate to differences in gel properties. Aesthetic improvement, subject satisfaction, and AE profiles post\u2010Day 14, however, were similar between filler groups.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jocd.15548","type":"journal-article","created":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T11:44:12Z","timestamp":1669981452000},"page":"119-127","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical outcomes after lip injection procedures\u2014Comparison of two hyaluronic acid gel fillers with different product properties"],"prefix":"10.1111","volume":"22","author":[{"given":"Said","family":"Hilton","sequence":"first","affiliation":[{"name":"Private practice Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6994-8877","authenticated-orcid":false,"given":"Konstantin","family":"Frank","sequence":"additional","affiliation":[{"name":"Department for Hand, Plastic and Aesthetic Surgery Ludwig \u2013 Maximilian University Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4892-2376","authenticated-orcid":false,"given":"Michael","family":"Alfertshofer","sequence":"additional","affiliation":[{"name":"Department for Hand, Plastic and Aesthetic Surgery Ludwig \u2013 Maximilian University Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7210-6566","authenticated-orcid":false,"given":"Sebastian","family":"Cotofana","sequence":"additional","affiliation":[{"name":"Department of Clinical Anatomy Mayo Clinic College of Medicine and Science Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,2]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"ASPS National clearinghouse of plastic surgery procedural Statistics.Plastic surgery statistics report 2019. Published Online2019:1\u201025.https:\/\/www.plasticsurgery.org\/documents\/News\/Statistics\/2019\/plastic\u2010surgery\u2010statistics\u2010full\u2010report\u20102019.pdf"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1683856"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000003244"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjaa137"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2015.03.032"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2008.34365.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2008.34251.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjz053"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000486"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1085-5629(96)80003-4"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.15548","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.15548","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.15548","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T09:42:22Z","timestamp":1692524542000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.15548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,2]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/jocd.15548"],"URL":"https:\/\/doi.org\/10.1111\/jocd.15548","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,2]]},"assertion":[{"value":"2022-10-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}