{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:02:11Z","timestamp":1787169731937,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T00:00:00Z","timestamp":1672099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Alopecia areata (AA) is a common non\u2010scarring hair loss disorder that affects children and adults with a great psychological burden because of its recurrent and sometimes treatment\u2010refractory nature.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To compare the efficacy of topical calcineurin inhibitor, topical potent steroid combined with vitamin D analogue versus topical superpotent steroid in treatment of localized AA.<\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n Sixty subjects with chronic (>1\u00a0year) localized (SALT score\u2009<\u200925%) AA, confirmed clinically and dermoscopically, were randomized into three groups. Group I used topical 0.03% tacrolimus (Tarolimus\u00ae), group II used topical potent steroid combined with vitamin D analogue (Daivobet\u00ae). and group III used topical superpotent steroid (Dermovate\u00ae). All patients continued a daily therapy for three successive months and were followed up for three other months. Assessment was done using PULL test, SALT score, and dermoscopic comparison before and after therapy.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Group II showed comparable statistical results to group III with lower values in a non\u2010statistically significant way. Group I achieved the least improvement among all groups.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Combined vitamin D analogues with potent steroid appears to be a more convenient treatment for localized AA than superpotent steroids because of less side effects and comparable efficacy. Tacrolimus needs further research or formula customization to be used as a topical therapy for AA.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jocd.15558","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T02:37:06Z","timestamp":1672195026000},"page":"1297-1303","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Comparative evaluation of the efficacy of topical tacrolimus 0.03% and topical calcipotriol 0.005% mixed with betamethasone dipropionate versus topical clobetasol 0.05% in treatment of alopecia areata: A clinical and trichoscopic study"],"prefix":"10.1111","volume":"22","author":[{"given":"Amany","family":"Nassar","sequence":"first","affiliation":[{"name":"Dermatology, Venereology &Andrology Department Zagazig University Hospitals, Zagazig University Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Elradi","sequence":"additional","affiliation":[{"name":"Dermatology, Venereology &Andrology Department Zagazig University Hospitals, Zagazig University Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Radwan","sequence":"additional","affiliation":[{"name":"Dermatology, Venereology &Andrology Department Zagazig University Hospitals, Zagazig University Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waleed","family":"Albalat","sequence":"additional","affiliation":[{"name":"Dermatology, Venereology &Andrology Department Zagazig University Hospitals, Zagazig University Zagazig 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study","volume":"14","author":"Cerman A","year":"2015","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12464"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-019-01943-8"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2021\/48438.14823"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.1.124"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.05.019"},{"issue":"6","key":"e_1_2_8_14_1","first-page":"133","article-title":"Efficacy of topical clobetasol propionate 0.05% ointment and topical tacrolimus 0.1% ointment in treatment of alopecia areata: RCT","volume":"16","author":"Ullah F","year":"2022","journal-title":"Pak J 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