{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T09:36:06Z","timestamp":1788428166692,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T00:00:00Z","timestamp":1675987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Alopecia areata (AA) is a challenging disease with variable treatment outcomes. Hair follicles express vitamin D receptors. Therefore, vitamin D3 may be promising for AA treatment through immunomodulatory mechanisms. The efficacy of bimatoprost in scalp AA treatment was reported by few studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the efficacy and safety of microneedling (MN) with topical vitamin D3 versus MN with bimatoprost in comparison with MN alone in the treatment of localized AA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Seventy\u2010five patients with localized AA were divided into three groups. The first group: 25 patients were treated with MN alone. The second group: 25 patients treated with MN combined with topical vitamin D3. The third group: 25 patients treated with MN combined with bimatoprost solution. The response was evaluated clinically and dermoscopically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the end of the study, all groups showed a statistically significant decrease in the SALT score compared to the baseline. The clinical response (regrowth scale): vitamin D and bimatoprost groups showed a statistically significant higher regrowth scale compared to MN alone group (<jats:italic>p<\/jats:italic>\u2010value\u00a0=\u00a00.000). After treatment, hair regrowth was significantly higher in MN combined with bimatoprost than in MN combined with topical vitamin D3. However, after 3\u00a0months of follow\u2010up, there was no statistically significant difference between both groups. Side effects were mild and transient in all groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Topical vitamin D3 and bimatoprost combined with MN are safe and effective therapeutic options for localized AA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15569","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T08:14:06Z","timestamp":1676016846000},"page":"1286-1296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Combined microneedling with topical vitamin <scp>D3<\/scp> or bimatoprost versus microneedling alone in the treatment of alopecia areata: A comparative randomized trial"],"prefix":"10.1111","volume":"22","author":[{"given":"Mona S.","family":"Ali","sequence":"first","affiliation":[{"name":"Faculty of Medicine (Girls) Al\u2010 Azhar University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4561-8229","authenticated-orcid":false,"given":"Hala S. A.","family":"Hafiz","sequence":"additional","affiliation":[{"name":"Faculty of Medicine (Girls) Al\u2010 Azhar University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6225-0839","authenticated-orcid":false,"given":"Naglaa A.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Faculty of Medicine (Girls) Al\u2010 Azhar University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2776-628X","authenticated-orcid":false,"given":"Sara Ahmed","family":"Galal","sequence":"additional","affiliation":[{"name":"Faculty of Medicine (Girls) Al\u2010 Azhar University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.18203\/issn.2455-4529.IntJResDermatol20204457"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14155"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10955.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12941"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S142450"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.129989"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14722"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2017.01.021"},{"key":"e_1_2_10_10_1","first-page":"616","article-title":"Topical calcipotriol therapy for mild\u2010to\u2010moderate alopecia areata: a retrospective study","volume":"14","author":"\u00c7erman AA","year":"2015","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12464"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2012.24.3.341"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-020-00379-7"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2017.1303480"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000371416"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14283"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.09.032"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01781.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16808"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15044"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14084"},{"key":"e_1_2_10_22_1","first-page":"6","article-title":"Triamcinolone acetonide mesotherapy in the treatment of recalcitrant patches of alopecia areata\u2010a pilot study","volume":"2","author":"Chandrashekar B","year":"2015","journal-title":"J Clin Dermatol Ther"},{"issue":"9","key":"e_1_2_10_23_1","first-page":"5285","article-title":"Vitamin D and alopecia areata: possible roles in pathogenesis and potential implications for therapy","volume":"11","author":"Lin X","year":"2019","journal-title":"Am J Transl Res"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14844"},{"key":"e_1_2_10_25_1","unstructured":"HafizHSA ElshahedLH AhmedHS.Bimatoprost versus triamcinolone acetonide with microneedling in the treatment of alopecia areata a comparative clinical and dermoscopic study. Sharm Derma 2018 The International Conference for Dermatology & Cosmetology"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2010.01522.x"},{"key":"e_1_2_10_27_1","first-page":"419","article-title":"An evaluation of the safety and efficacy of bimatoprost for eyelash growth in pediatric subjects","volume":"10","author":"Borchert M","year":"2016","journal-title":"Clin Ophthalmol"},{"issue":"5","key":"e_1_2_10_28_1","article-title":"Topical treatment of eyebrow hypotrichosis with Bimatoprost 0.03% solution case report and literature review","volume":"10","author":"Riahi RR","year":"2018","journal-title":"Cureus"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.84768"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2008.03692.x"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04581.x"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-218156"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.15569","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.15569","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.15569","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T22:11:34Z","timestamp":1692569494000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.15569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,10]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/jocd.15569"],"URL":"https:\/\/doi.org\/10.1111\/jocd.15569","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,10]]},"assertion":[{"value":"2022-09-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}