{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:37:46Z","timestamp":1787614666661,"version":"build-2736575974"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,25]],"date-time":"2022-12-25T00:00:00Z","timestamp":1671926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Dermal fillers for soft tissue augmentation have become increasingly popular among patients of all ages and ethnicities. With more widespread use, there has been an increased incidence of adverse reactions, one of which is the granulomatous foreign body reaction (GFBR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials &amp; Methods<\/jats:title><jats:p>We present a three patient case series in which GFBR secondary to dermal filler was successfully treated with a multi\u2010leveled approach. The first modality involves intralesional injection of a mixture containing 1\u00a0cc of 5\u2010fluorouracil (5\u2010FU), 0.5\u00a0cc of dexamethasone sodium phosphate, and 0.1\u00a0cc of triamcinolone 10. The lesion is injected intradermally in small aliquots, similar to scar treatment. The patient then takes colchicine 1.2\u00a0mg loading dose on day 1, then 0.6\u00a0mg twice per day for 4\u2009days concurrently with naproxen 500\u2009mg orally once daily for 5\u20137\u2009days. This process may be repeated in 6\u2009weeks if the lesions have not resolved and PDL laser may be employed for residual post\u2010inflammatory erythema.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All three patients presented in this case series had significant aesthetic improvement in their dermal filler\u2010derived foreign body granulomatous reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>GFBR provides both a medical and aesthetic issue for these patients including mental distress, pain, and dysfunction, therefore having an effective treatment for GFBR will affect medical management of these patients, improving patient outcomes and satisfaction. Our proposed regimen for GFBR has been shown to be highly efficacious and safe for these patients, providing a significant improvement in both function and cosmesis of the area.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15579","type":"journal-article","created":{"date-parts":[[2022,12,25]],"date-time":"2022-12-25T18:58:25Z","timestamp":1671994705000},"page":"1233-1237","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Novel management of granuloma formation secondary to dermal filler: A multi\u2010modality approach"],"prefix":"10.1111","volume":"22","author":[{"given":"Alexandra","family":"Bowles","sequence":"first","affiliation":[{"name":"Larkin Community Hospital Palm Springs Campus Dermatology Residency  Hialeah Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Ghalili","sequence":"additional","affiliation":[{"name":"SUNY Downstate College of Medicine  Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oben B.","family":"Ojong","sequence":"additional","affiliation":[{"name":"Heights Dermatology and Aesthetics  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella F.","family":"Vasile","sequence":"additional","affiliation":[{"name":"Hollywood Dermatology  Hollywood Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumeng M.","family":"Li","sequence":"additional","affiliation":[{"name":"Conway Medical Center  Conway South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shino Bay","family":"Aguilera","sequence":"additional","affiliation":[{"name":"Shino Bay Dermatology  Fort Lauderdale Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16027"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.5999\/aps.2015.42.2.232"},{"issue":"9","key":"e_1_2_10_4_1","first-page":"46","article-title":"Easy as PIE (post\u2010inflammatory erythema)","volume":"6","author":"Bae\u2010Harboe YSC","year":"2013","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.01.085"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-12-844605"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2006.32117"},{"issue":"9","key":"e_1_2_10_8_1","first-page":"1142","article-title":"Successful treatment of calcium Hydroxylapatite nodules with intralesional 5\u2010fluorouracil, dexamethasone, and triamcinolone","volume":"15","author":"Aguilera SB","year":"2016","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/08910600601149619"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199040010-00006"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.01.010"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2020.1672537"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000561"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/sder.2000.18369"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001227"}],"container-title":["Journal of Cosmetic 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