{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T13:10:43Z","timestamp":1792242643382,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:00:00Z","timestamp":1672963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003970","name":"Isfahan University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Melasma is a hyperpigmentary disorder causing cosmetic disfigurement. We aimed to compare the efficacy and safety of tranexamic acid (TXA) microinjections with TXA mesoneedling for facial melasma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This randomized assessor\u2010blind split\u2010face controlled trial included patients with symmetric facial melasma. One side of the face received TXA (100\u2009mg\/ml) mesoneedling and the other side intradermal TXA microinjections. The interventions were repeated three times with 4\u2010week intervals (weeks 0, 4, and 8). The primary outcome was improvement in modified Melasma Area and Severity Index (mMASI) 4\u2009weeks after the final treatment session. Secondary outcomes were complications and patient satisfaction with the treatments evaluated by a visual analog scale (VAS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All 27 patients included in the study were female (mean age: 44.22\u2009\u00b1\u20098.39\u2009years). Both groups were comparable in terms of mMASI scores before and after treatment (standardized mean difference [SMD]\u00a0=\u00a00.32, 95% confidence interval [CI] \u22120.22; 0.85, <jats:italic>p<\/jats:italic>\u00a0=\u20090.248 and SMD\u00a0=\u00a0\u22120.13, 95% CI \u22120.66; 0.40, <jats:italic>p<\/jats:italic>\u00a0=\u20090.633, respectively). The mMASI score change from baseline was not different (SMD\u00a0=\u00a0\u22120.39, 95% CI \u22120.93; 0.15, <jats:italic>p<\/jats:italic>\u00a0=\u20090.157). However, patient satisfaction was significantly higher with TXA mesoneedling (SMD\u00a0=\u00a00.77, 95% CI 0.21; 1.32, <jats:italic>p<\/jats:italic>\u00a0=\u20090.007). Post\u2010inflammatory hyperpigmentation occurred in one patient in the TXA mesoneedling group. Erythema, scaling, and edema were significantly higher with TXA mesoneedling (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>TXA mesoneedling was comparable with TXA microinjection in the treatment of facial melasma, while patient satisfaction was significantly higher with TXA mesoneedling; however, the high frequency of complications occurring with this treatment should be taken into account.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15580","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T09:04:54Z","timestamp":1672995894000},"page":"1238-1244","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Tranexamic acid microinjections versus tranexamic acid mesoneedling in the treatment of facial melasma: A randomized assessor\u2010blind split\u2010face controlled trial"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8428-6186","authenticated-orcid":false,"given":"Nazila","family":"Poostiyan","sequence":"first","affiliation":[{"name":"Skin Diseases and Leishmaniasis Research Center Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6602-6252","authenticated-orcid":false,"given":"Maryam","family":"Alizadeh","sequence":"additional","affiliation":[{"name":"Skin Diseases and Leishmaniasis Research Center Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6019-8985","authenticated-orcid":false,"given":"Zabihollah","family":"Shahmoradi","sequence":"additional","affiliation":[{"name":"Skin Diseases and Leishmaniasis Research Center Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0618-5512","authenticated-orcid":false,"given":"Farahnaz","family":"Fatemi Naeini","sequence":"additional","affiliation":[{"name":"Skin Diseases and Leishmaniasis Research Center Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,6]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.13430"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.164415"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.174024"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13182"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199957060-00017"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.164416"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2017.1392476"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.03.001"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-017-0195-0"},{"issue":"2","key":"e_1_2_13_11_1","first-page":"E7","article-title":"Treatment of melasma using tranexamic acid: what's known and what's next","volume":"101","author":"Sheu SL","year":"2018","journal-title":"Cutis"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.185468"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20154748"},{"issue":"1","key":"e_1_2_13_14_1","first-page":"23","article-title":"Effect of combination of microneedling with tranexamic acid on modified MASI score in patients of melasma","volume":"31","author":"Hassan B","year":"2021","journal-title":"Journal of Pakistan Association of Dermatologists"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.118403"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.10.051"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/1467-8721.ep10768783"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/03610926.2015.1134575"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14924"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14257"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000002449"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.13575"},{"key":"e_1_2_13_23_1","first-page":"555","article-title":"A split face comparative study between intradermal tranexamic acid and erbium\u2010YAG laser in treatment of melasma","volume":"1","author":"Otb S","year":"2021","journal-title":"J Dermatolog Treat"},{"issue":"2","key":"e_1_2_13_24_1","first-page":"44","article-title":"Treatment of melasma with intralesional tranexamic acid versus cryotherapy","volume":"15","author":"Gharib K","year":"2022","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.IDOJ_22_19"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8350317"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2015.1115812"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.15580","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.15580","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.15580","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T22:11:05Z","timestamp":1692569465000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.15580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,6]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/jocd.15580"],"URL":"https:\/\/doi.org\/10.1111\/jocd.15580","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,6]]},"assertion":[{"value":"2022-05-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}