{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:05:41Z","timestamp":1791266741833,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:00:00Z","timestamp":1672963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The development of alopecia areata is suggested to be influenced by intestinal permeability and gut dysbiosis. Claudin\u20103, an essential component of tight junctions which may act as an indicator of intestinal barrier integrity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The study's objective was to evaluate the plasma concentration level of Claudin\u20103 in alopecia areata patients and its relationship to the severity of the condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>In this case\u2013control study, 50 alopecia areata patients and 30 healthy age and sex controls were involved. An enzyme\u2010linked immunosorbent assay was used to determine the concentration of claudin\u20103 in the blood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with alopecia areata had significantly higher plasma claudin\u20103 concentrations than healthy controls [median (interquartile range), 7.73\u2009ng\/ml (4.49\u201333.7) vs. 6.14\u2009ng\/ml (4.45\u201315.6), <jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.005]. Positive relations were found between claudin\u20103 and SALT score (<jats:italic>r<\/jats:italic>\u00a0=\u20090.675 &amp; <jats:italic>p<\/jats:italic>\u2010value\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Claudin\u20103, a gut permeability biomarker, is elevated in alopecia areata and correlates with disease severity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15582","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T08:44:46Z","timestamp":1672994686000},"page":"1377-1381","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Claudin\u20103 is a novel intestinal integrity marker in patients with alopecia areata: Correlation with the disease severity"],"prefix":"10.1111","volume":"22","author":[{"given":"Dina","family":"Rafik","sequence":"first","affiliation":[{"name":"Dermatology Department, Faculty of Medicine Benha University  Benha Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihab","family":"Younis","sequence":"additional","affiliation":[{"name":"Dermatology Department, Faculty of Medicine Benha University  Benha Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2222-4382","authenticated-orcid":false,"given":"Rana","family":"Atef","sequence":"additional","affiliation":[{"name":"Clinical Pathology and Chemistry Department, Faculty of Medicine Benha University  Benha Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0623-7987","authenticated-orcid":false,"given":"Hanaa","family":"Eid","sequence":"additional","affiliation":[{"name":"Dermatology Department, Faculty of Medicine Benha University  Benha Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,6]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"397","article-title":"Epidemiology and burden of alopecia areata: a systematic review","volume":"8","author":"Villasante A","year":"2015","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13933"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2016.10.004"},{"key":"e_1_2_11_5_1","first-page":"e404","article-title":"Alopecia areata. 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