{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T01:09:44Z","timestamp":1780535384009,"version":"3.54.1"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T00:00:00Z","timestamp":1675123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The potential as a depigmenting agent, sun protection, and healthy benefits is indicated by the sun protection factor, radical scavenging, and tyrosinase inhibitory activities of <jats:italic>Alpinia galanga<\/jats:italic> (wild).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>A stable emulgel containing <jats:italic>A<\/jats:italic> .<jats:italic>galanga<\/jats:italic> (wild) extract is prepared. This emulgel is then characterized by in vitro evaluation and identification of contents by LC\u2010ESI\u2010MS<jats:sup>2<\/jats:sup>. In vivo performance is counted in terms of moisturizing, melanin level, erythema, sebum, skin fine pores and large pores analysis, and other related physiological skin parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>DPPH radical scavenging activity, total phenolic and flavonoid counts were used to measure the free radical scavenging and tyrosinase inhibitory capability of <jats:italic>A<\/jats:italic> .<jats:italic>galanga<\/jats:italic> (wild) extract, respectively. LC\u2010ESI\u2010MS<jats:sup>2<\/jats:sup> used for phytochemical analysis. Emulgels synthesize, and their globule size, Ultracentrifugation, pH, and conductivity were all evaluated. Among the developed formulations, the optimal emulgels formulation underwent 90\u2010day stability tests for organoleptic characteristics and rheology at 8\u00b0C, 25\u00b0C, 40\u00b0C, and 40\u00b0C\u2009+\u200975% RH (relative humidity). Using sebumeter\u00ae, mexameter\u00ae, and corneometer\u00ae, changes in skin physiological parameters were assessed over the course of 12\u2009weeks in 13 healthy male, Asian volunteers. VisioFace\u00ae is used for computational analysis of high\u2010resolution pictures to determine the % area, fine pore counts, and large pore counts of the skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The antioxidant, tyrosinase inhibitory potential and counts of total phenolic and flavonoids of <jats:italic>A<\/jats:italic> .<jats:italic>galanga<\/jats:italic> (wild) extract were impressive (85%, 75%, and 48.0\u00a0mg GAE\/g and 14.37\u2009mg quercetin\/g, respectively). In terms of stability evaluation, globule size (0.7528\u2009\u00b1\u20090.192\u00a0<jats:italic>\u03bc<\/jats:italic>m). Optimized <jats:italic>A<\/jats:italic> .<jats:italic>galanga<\/jats:italic> (wild) ethanol aqueous (AGEA) extract loaded emulgel was stable in terms of organoleptic and in vitro evaluation. The AGEA formulation significantly reduced the amount of sebum, erythema, fine pore counts, large pore counts, fine pore % area and large pores area percentage while significantly improved the moisture and elasticity of the skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A stable <jats:italic>A<\/jats:italic> .<jats:italic>galanga<\/jats:italic> (wild) extract loaded emulgel was successfully produced that improved the skin physiological parameters in terms of skin's sebum, erythema, moisturizing, melanin, and pores.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15623","type":"journal-article","created":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T10:45:18Z","timestamp":1675161918000},"page":"1628-1641","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Profiling of phytochemicals using <scp>LC\u2010ESI\u2010MS<sup>2<\/sup><\/scp>, in vitro, in vivo characterization and cosmeceutical effects of <i>Alpinia galanga<\/i> (wild) extract loaded emulgel"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4834-7287","authenticated-orcid":false,"given":"Muhammad Shahzad","family":"khan","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy The Islamia University of Bahawalpur  Bahawalpur Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3172-2570","authenticated-orcid":false,"given":"Qazi","family":"Adnan","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy The Islamia University of Bahawalpur  Bahawalpur Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveed","family":"Akhtar","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy The Islamia University of Bahawalpur  Bahawalpur Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,31]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Effects of the zingiberaceae spice extracts on growth and morphological changes of foodborne pathogens","author":"Oonmetta\u2010aree J","year":"2005"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2010.08.032"},{"issue":"2","key":"e_1_2_11_4_1","first-page":"143","article-title":"Alpinia galanga willd.\u2013an overview on phyto\u2010pharmacological properties","volume":"1","author":"Chudiwal A","year":"2010","journal-title":"IJNPR"},{"issue":"2","key":"e_1_2_11_5_1","first-page":"73","article-title":"Analysis of the essential oils of the leaves, stems, rhizomes and roots of the medicinal plant Alpinia galanga from southern India","volume":"53","author":"Jirovetz L","year":"2003","journal-title":"Acta Pharm"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.12419"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13205-012-0089-x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/phrev.phrev_55_16"},{"issue":"2","key":"e_1_2_11_9_1","first-page":"54","article-title":"Study of chemical composition and phytochemical analysis of Alpinia galanga rhizomes extracts by HPTLC fingerprinting","volume":"2","author":"Jain AP","year":"2016","journal-title":"AJPP"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.5530\/pc.2012.3.7"},{"issue":"6","key":"e_1_2_11_11_1","first-page":"2467","article-title":"Phytochemical analysis of siddha polyherbal formulation arathai kudineer churnam","volume":"7","author":"Ganesan R","year":"2018","journal-title":"J Pharmacogn Phytochem"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2478\/v10007-010-0020-0"},{"issue":"5","key":"e_1_2_11_13_1","first-page":"1653","article-title":"Emulgel: an emergent tool in topical drug delivery","volume":"5","author":"Hardenia A","year":"2014","journal-title":"IJNPR"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.22159\/ijpps.2017v9i12.21599"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-4514.2009.00258.x"},{"issue":"2","key":"e_1_2_11_16_1","first-page":"358","article-title":"Antioxidant activities and antioxidative components in extracts of Alpinia galanga (L.) 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