{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T19:18:36Z","timestamp":1768072716866,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,1,22]],"date-time":"2023-01-22T00:00:00Z","timestamp":1674345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cutaneous lupus erythematosus is an umbrella term for a group of autoimmune connective tissue disorders affecting the skin. Discoid lupus erythematosus (DLE) is the chronic condition and most common form of cutaneous lupus erythematosus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>Current therapies of DLE are challenging and not completely satisfactory, highly expensive, off\u2010label, or poorly available (like antimalarials due to COVID\u201019 outbreaks). Nicotinamide, also called niacinamide, is a water\u2010soluble form of vitamin B3 (niacin). Its multiple effects let us think that nicotinamide could be a therapy for lupus\u2010associated skin lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a prospective randomized double\u2010blind clinical trial on 60 subjects diagnosed with Discoid lupus erythematosus using topical Nicotinamide 2% and 4% preparations in form of cream and gel on skin and scalp lesions. Control group was included using only cream\/gel base as placebo control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Obtained data showed that topical Nicotinamide can be used for the treatment of DLE as adjuvant to other treatment regimens with good cosmetic results and minimal side effects. Topical 4% Nicotinamide is superior to 2% preparation in response but associated with a higher incidence of irritation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Topical Nicotinamide can be used for the treatment of DLE as an adjuvant to other treatment regimens with good cosmetic results and minimal side effects. Further trials with long\u2010term therapy, follow\u2010up period, and bigger sample sizes are required.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15628","type":"journal-article","created":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T05:18:41Z","timestamp":1674451121000},"page":"1647-1657","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Topical niacinamide (Nicotinamide) treatment for discoid lupus erythematosus (<scp>DLE<\/scp>): A prospective pilot study"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3560-7289","authenticated-orcid":false,"given":"Ahmed H.","family":"Nouh","sequence":"first","affiliation":[{"name":"Department of Dermatology Venereology and Andrology Faculty of Medicine of Al\u2010Azhar University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed R.","family":"Elshahid","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Andrology Faculty of Medicine of Al\u2010Azhar University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9744-9506","authenticated-orcid":false,"given":"Ahmed S.","family":"Kadah","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology at Al\u2010Hussein University Hospital of Al\u2010Azhar University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youssef A.","family":"Zeyada","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine of Al\u2010Azhar University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.775353"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2014.01.021"},{"key":"e_1_2_10_4_1","volume-title":"Systemic lupus erythematosus","author":"Lahita RG","year":"2011"},{"key":"e_1_2_10_5_1","volume-title":"StatPearls [Internet]","author":"McDaniel B","year":"2022"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.126020"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14015"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S184824"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.142483"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25153323"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2003.02031.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/b9pp00146h"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000359974"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10081315"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.4061\/2010\/157591"},{"issue":"10","key":"e_1_2_10_16_1","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.2460\/javma.1992.200.10.1497","article-title":"Use of tetracycline and niacinamide for treatment of autoimmune skin disease in 31 dogs","volume":"200","author":"White SD","year":"1992","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.435"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb01167.x"},{"key":"e_1_2_10_19_1","unstructured":"PhD QL MD Second Xiangya Hospital of Central South University National Natural Science Foundation of China Hunan Provincial Natural Science Foundation of China National Key Clinical Specialty Construction Project of China.An Open\u2010label Study for Assessing the Efficacy and Safety of Nicotinamide Treatment for Lupus\u2010associated Skin Lesions in Patients With Cutaneous Lupus Erythematosus or Systemic Lupus Erythematosus [Internet].clinicaltrials.gov.2021[cited 2022 Jul 28]. Available from:https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03260166"},{"issue":"6","key":"e_1_2_10_20_1","first-page":"360","article-title":"Nicotinamide in dermatology and photoprotection","volume":"9","author":"Surjana D","year":"2011","journal-title":"Skinmed"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04834.x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02375.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.01.110"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-6116"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12078"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2002.63.491"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.15628","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.15628","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.15628","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T19:14:40Z","timestamp":1728760480000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.15628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,22]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1111\/jocd.15628"],"URL":"https:\/\/doi.org\/10.1111\/jocd.15628","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,22]]},"assertion":[{"value":"2022-11-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}