{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:04:17Z","timestamp":1790345057435,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T00:00:00Z","timestamp":1673827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>This feasibility study describes the effects of Nano\u2010pulse stimulation\u2122 (NPS\u2122) technology using the CellFX\u2122 System on acne vulgaris of the back with the objectives of demonstrating safety and effectiveness. The CellFX System applies nanosecond pulses of electrical energy to induce highly localized regulated cell death (RCD) in the cellular structures of the targeted zone with no thermal effect on the tissue and negligible effects on surrounding non\u2010cellular components.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>Seventeen subjects were enrolled at two sites with thirteen subjects completing treatment. Three 7\u2009X\u20097\u2009cm regions containing at least five bacne lesions each were identified, one region treated with the CellFX across three treatment sessions, the second region treated as a sham using microneedle tip placement without delivering energy, and the third as an untreated control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CellFX\u2010treated areas showed an average reduction of acne lesions of 82% by 90\u2009days post\u2010last procedure. Acne improvement was observed in 100% of CellFX\u2010treated regions compared to 39% improvement in Sham regions and 31% improvement in the control regions. The most common skin effects were erythema and hyperpigmentation observed in 23% and 92% of the subjects, respectively, at the last timepoint. No serious adverse events were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CellFX is a safe and effective procedure for clearing back acne.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15633","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T14:34:15Z","timestamp":1673879655000},"page":"1545-1553","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Safety and effectiveness of nano\u2010pulse stimulation\u2122 technology to treat acne vulgaris of the back"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8255-6552","authenticated-orcid":false,"given":"Bruce E.","family":"Katz","sequence":"first","affiliation":[{"name":"Juva Skin and Laser Center  New York New York 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