{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:06:22Z","timestamp":1790877982969,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T00:00:00Z","timestamp":1677542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To explore the relationship between melanocyte stem cells in the hair follicle bulge and hair graying so as to fully understand their key role in the pathogenesis of hair graying.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The published articles about \u201chair graying, hair color, pigmentation disorders\u201d and \u201cmelanocyte stem cells, melanocyte\u201d were searched and analyzed in PubMed to explore their relationship.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Melanocytes in hair bulb are involved in the pathogenesis of hair graying as well as the melanocyte stem cells in hair follicle bulge also play important roles in the formation of hair graying through some ways.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Loss of melanocyte stem cells in hair follicle bulge is one of the main reasons of hair graying, and more researches are needed to explain the underlying mechanisms of ectopic differentiation of melanocyte stem cells in different individual.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15652","type":"journal-article","created":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T18:09:24Z","timestamp":1677607764000},"page":"1720-1723","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Melanocyte stem cells and hair graying"],"prefix":"10.1111","volume":"22","author":[{"given":"Xiaojiao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Dermatology University\u2010Town Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Dermatology University\u2010Town Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiezhi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2225-7651","authenticated-orcid":false,"given":"Hengguang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(00)00210-2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35557"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2018.30.4.397"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14260"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.108.4.605"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1101\/sqb.2008.73.024"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2011.00855.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/416854a"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02161"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13856"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.03.037"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12251"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2007.03.002"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2008.03.009"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00762-6"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099593"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17071144"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2003648"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2009.12.010"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.340281.120"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21000"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11847"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12319337"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2010.11.029"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1959.01560140090013"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-1935-3"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14309"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11095.x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/276627a0"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(00)00157-8"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12090"},{"issue":"6","key":"e_1_2_8_33_1","first-page":"401","article-title":"The skin's antioxidant systems","volume":"10","author":"Pugliese PT","year":"1998","journal-title":"Dermatol Nurs"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-0889"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2017.09.001"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/207877a0"},{"issue":"15","key":"e_1_2_8_37_1","first-page":"3546","article-title":"Accelerated disappearance of melanocytes in bcl\u20102\u2010deficient mice","volume":"56","author":"Yamamura K","year":"1996","journal-title":"Cancer Res"},{"issue":"11","key":"e_1_2_8_38_1","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13273","article-title":"Hair graying with aging in mice carrying oncogenic RET","volume":"19","author":"Machiko I","year":"2020","journal-title":"Aging Cell"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2012.08.020"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijt.ijt_89_18"},{"issue":"11","key":"e_1_2_8_41_1","article-title":"Amelioration of androgenetic alopecia by algal oligosaccharides prepared by Deep\u2010Sea bacterium biodegradation","volume":"29","author":"Min J","year":"2020","journal-title":"Front Microbiol"},{"issue":"12","key":"e_1_2_8_42_1","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.1456","article-title":"Comorbidity in trichotillomania (hair\u2010pulling disorder): a cluster analytical approach","volume":"9","author":"Christine L","year":"2019","journal-title":"Brain Behav"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.15652","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.15652","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.15652","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T18:32:27Z","timestamp":1700677947000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.15652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,28]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1111\/jocd.15652"],"URL":"https:\/\/doi.org\/10.1111\/jocd.15652","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,28]]},"assertion":[{"value":"2022-10-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}