{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T01:15:05Z","timestamp":1781140505453,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T00:00:00Z","timestamp":1678233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008040","name":"Kao Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008040","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Redness of the facial skin is an important cosmetic concern. Although qualitative and quantitative modifications of sebum on the skin surface are major pathogenic factors of chronic inflammatory skin conditions, the relationship between skin redness, sebum, and mild inflammation on the cheeks of healthy subjects remains elusive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We aimed to explore the correlation between cheek redness and sebum and inflammatory cytokines in the stratum corneum (SC) of healthy subjects. We also examined the effects of representative sebum lipids on the gene expression of inflammatory cytokines in cultured keratinocytes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>This study included 198 healthy participants. Skin sebum was analyzed using flow injection analysis, and skin redness was assessed using a spectrophotometer. Inflammatory cytokines in tape\u2010stripped SC were measured using enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cheek redness parameters positively correlated with the amount of skin sebum and the proportion of monounsaturated free fatty acids (C16:1 and C18:1) in the sebum. They also positively correlated with the interleukin (IL)\u201036\u03b3\/IL\u201037 ratio in the SC. Among the representative sebum lipids examined, oleic acid (C18:1, <jats:italic>cis<\/jats:italic>\u20109) dose\u2010 and time\u2010dependently regulated the mRNA expression of IL\u201036\u03b3 and IL\u201037 in cultured keratinocytes, and this effect was attenuated by the <jats:italic>N<\/jats:italic>\u2010methyl\u2010D\u2010aspartate (NMDA)\u2010type glutamate receptor antagonist, MK801.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Skin surface sebum may be related to cheek redness in healthy subjects, and oleic acid\u2010induced IL\u201036\u03b3 through NMDA\u2010type glutamate receptors may be a link between them. Our study provides a possible skincare strategy for mitigating unfavorable increase in skin redness by targeting the facial skin sebum, particularly oleic acid.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15697","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T07:28:19Z","timestamp":1678346899000},"page":"2308-2317","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Oleic acid\u2010induced interleukin\u201036\u03b3: A possible link between facial skin redness and sebum"],"prefix":"10.1111","volume":"22","author":[{"given":"Akane","family":"Kawamoto","sequence":"first","affiliation":[{"name":"Biological Science Research, Kao Corporation  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Kuwano","sequence":"additional","affiliation":[{"name":"Biological Science Research, Kao Corporation  Tochigi 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