{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T21:02:05Z","timestamp":1787950925261,"version":"build-2784847793"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T00:00:00Z","timestamp":1679875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Dermocosmetic products are often used to maintain or enhance the tolerance and effectiveness of medical anti\u2010acne therapies. Recent discoveries about the pathophysiology of acne\u2010prone skin indicate that skincare products may help maintain homeostasis around the sebaceous gland progenitor cells, thereby preventing microcomedone formation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the tolerance and effectiveness of a dermocosmetic product containing <jats:italic>Silybum marianum<\/jats:italic> fruit extract (SMFE) in adolescents and young adults with acne\u2010prone skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>This real\u2010life, international, observational, multicenter study was conducted in patients aged 12\u201325\u2009years with mild\u2010to\u2010moderate acne. Patients (<jats:italic>N<\/jats:italic>\u00a0=\u00a04230) used the product twice daily for 8\u201312\u2009weeks, either alone before (\u201cinitial group\u201d) or after an anti\u2010acne therapy (\u201cmaintenance group\u201d), or in association with their usual prescribed anti\u2010acne therapies (\u201cassociation group\u201d). The tolerance, effectiveness, and cosmetic properties of the product were assessed. Patient quality of life (QoL) was also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Dermatologists rated the tolerance of the product as \u201cgood\u201d or \u201cvery good\u201d in about 95% of the patients and the effectiveness of the product as \u201ceffective\u201d or \u201chighly effective\u201d in about 80% of the patients, with a significant reduction in the mean global evaluation of acne (GEA) grade (\u221236%\u2009\u00b1\u200939%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) at study end. The QoL of most patients (80%) improved by the end of the study, and the majority (79% to 94%) appreciated the cosmetic properties of the product. Overall, the product was a clinical success in &gt;84% of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This dermocosmetic product can be used by adolescents and young adults with acne\u2010prone skin to limit the initial or chronic use of medical anti\u2010acne therapies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15705","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T03:09:53Z","timestamp":1679972993000},"page":"2259-2267","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Tolerability and effectiveness of a dermocosmetic product containing Silybum marianum fruit extract in adolescents and young adults with acne\u2010prone skin: An international, phase IV, longitudinal study"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1780-0824","authenticated-orcid":false,"given":"Foteini","family":"Bageorgou","sequence":"first","affiliation":[{"name":"Private Dermatology &amp; Laser Clinic  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9506-1778","authenticated-orcid":false,"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Beausillon","sequence":"additional","affiliation":[{"name":"Association France3a, France Acn\u00e9 Ados  Vincennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Stennevin","sequence":"additional","affiliation":[{"name":"Laboratoires Dermatologiques Av\u00e8ne Pierre Fabre Dermo\u2010Cosm\u00e9tique  Lavaur 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