{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T07:11:02Z","timestamp":1792393862496,"version":"4.4.0"},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:00:00Z","timestamp":1680220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Carboxytherapy is defined as intradermal and\/or subcutaneous microinjections of sterile purified carbon dioxide into different parts of the body for therapeutic aims. The vasodilatation effect and intradermal collagen reorganization associated with carboxytherapy have advantages for aesthetic dermatology and cosmetology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>In the current article, we have reviewed some of the most important indications of this modality in dermatology and aesthetic dermatology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Our review is a narrative one which has gathered some of the most important indications of carboxytherapy in dermatology and cosmetology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Carboxytherapy has successfully been applied for some dermatologic and cosmetic conditions among which skin aging, cellulite, localized fat deposits, striae distensae, infraorbital hyperpigmentation, scar, lymphedema, androgenetic alopecia, alopecia areata, psoriasis, morphea, and vitiligo are the most important.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Carboxytherapy can be considered as a safe, minimally\u2010invasive modality used for rejuvenation, restoration, and recondition of the skin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15741","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T09:09:16Z","timestamp":1680253756000},"page":"2399-2407","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["An overview of the role of carboxytherapy in dermatology"],"prefix":"10.1111","volume":"22","author":[{"given":"Nooshin","family":"Bagherani","sequence":"first","affiliation":[{"name":"Department of Dermatology Arak University of Medical sciences  Markazi Province Arak Iran"},{"name":"Department of Molecular Medicine, School of Advanced Technologies in Medicine Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce R.","family":"Smoller","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Rochester School of Medicine and Dentistry  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gholamreza","family":"Tavoosidana","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, School of Advanced Technologies in Medicine Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Ghanadan","sequence":"additional","affiliation":[{"name":"Department of dermatopathology, Razi Hospital and Department of Pathology, Cancer Institute Imam Khoemini Hospital Complex  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5933-2913","authenticated-orcid":false,"given":"Uwe","family":"Wollina","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology, St\u00e4dtisches Klinikum Dresden Academic Teaching Hospital  Friedrichstrasse 41 Dresden 01067 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torello","family":"Lotti","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze della Comunicazione Universit\u00e0 degli Studi Guglielmo Marconi  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,31]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2021.08.020"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12501"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12699"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.15761\/GOD.1000202"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S102503"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2012.00633.x"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14834"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2021.01.028"},{"issue":"5","key":"e_1_2_14_10_1","first-page":"42","article-title":"Carboxytherapy non\u2010invasive method in dermatology, aesthetic dermatology and some other branches of medicine","volume":"3","author":"Zelenkov\u00e1 H","year":"2019","journal-title":"Acta Sci Med Sci"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2021.1880598"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13337"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.5856"},{"issue":"6","key":"e_1_2_14_14_1","first-page":"e404","article-title":"Alopecia areata. Current situation and perspectives","volume":"115","author":"Ju\u00e1rez\u2010Rend\u00f3n KJ","year":"2017","journal-title":"Arch Argent Pediatr"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09114"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2006.21.1.90"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-018-0889-y"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13362"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.2217\/pmt-2020-0003"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-009-9459-0"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2017.1400175"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12242"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-018-1222-y"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-004-2068-z"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-010-9638-z"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002660010116"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13844"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12465"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12481"},{"key":"e_1_2_14_30_1","first-page":"836","article-title":"Efficacy of carboxytherapy in treatment of stretch marks","volume":"5","author":"Farouk S","year":"2021","journal-title":"Sci J Al\u2010Azhar Med Fac Girls"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14980"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/cosmetics8020026"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103\u2010021\u201003274\u20105"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13942"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001560"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12561"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1024\/0301-1526\/a000539"},{"issue":"2","key":"e_1_2_14_38_1","first-page":"79","article-title":"Carboxytherapy: effects on microcirculation and its use in the treatment of severe lymphedema","volume":"8","author":"Varlaro V","year":"2007","journal-title":"A Review Acta Phlebologica"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12494"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.24959\/ubphj.18.192"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2018.04.005"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10194517"},{"issue":"1","key":"e_1_2_14_43_1","article-title":"Connective tissue diseases: treatment of localized morphea in face and body using carboxytherapy, case report","volume":"74","author":"El\u2010Fakahany H","year":"2016","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2010.01139.x"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15229"},{"key":"e_1_2_14_46_1","volume-title":"What you should know about carboxytherapy","author":"Cobb C","year":"2022"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.15741","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T10:29:23Z","timestamp":1691749763000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.15741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,31]]},"references-count":45,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1111\/jocd.15741"],"URL":"https:\/\/doi.org\/10.1111\/jocd.15741","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,31]]},"assertion":[{"value":"2022-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}